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anti-TRPV4 antibody :: Rabbit transient receptor potential cation channel, subfamily V, member 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711589 anti-TRPV4 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

transient receptor potential cation channel, subfamily V, member 4 (TRPV4), Polyclonal Antibody

 Also Known As   

Rabbit anti-human transient receptor potential cation channel, subfamily V, member 4 polyclonal Antibody

 Product Synonym Names    transient receptor potential cation channel; subfamily V; member 4; TRPV4; OTRPC4; TRP12; VR-OAC; VRL-2; VRL2; VROAC
 Product Gene Name   

anti-TRPV4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613508
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human TRPV4
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16485 / sc-47527 / sc-98592
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TRPV4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TRPV4 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TRPV4. It may not necessarily be applicable to this product.
 NCBI GI #    22547184
 NCBI GeneID    59341
 NCBI Accession #    NP_067638.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_021625.4 [Other Products]
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 UniProt Secondary Accession #    Q17R79; Q2Y122; Q2Y123; Q2Y124; Q86YZ6; Q8NDY7; Q8NG64; Q96Q92; Q96RS7; Q9HBC0; B7ZKQ6 [Other Products]
 UniProt Related Accession #    Q9HBA0 [Other Products]
 Molecular Weight    85,884 Da [Similar Products]
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 NCBI Official Full Name    transient receptor potential cation channel subfamily V member 4 isoform a
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily V, member 4
 NCBI Official Symbol    TRPV4 [Similar Products]
 NCBI Official Synonym Symbols   
SMAL; VRL2; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily V member 4; osm-9-like TRP channel 4; vanilloid receptor-like channel 2; transient receptor potential protein 12; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; vanilloid receptor-related osmotically activated channel
 UniProt Protein Name    Transient receptor potential cation channel subfamily V member 4
 UniProt Synonym Protein Names   
Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
 Protein Family    Transient receptor potential cation channel subfamily
 UniProt Gene Name    TRPV4 [Similar Products]
 UniProt Synonym Gene Names    VRL2; VROAC; TrpV4; OTRPC4; TRP12; VRL-2; VR-OAC [Similar Products]
 UniProt Entry Name    TRPV4_HUMAN
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 NCBI Summary for TRPV4    This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
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 UniProt Comments for TRPV4    TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: cortical actin cytoskeleton; adherens junction; growth cone; cell surface; focal adhesion; lamellipodium; cytoplasmic microtubule; integral to membrane; plasma membrane; cytoplasmic vesicle; cilium; filopodium

Molecular Function: microtubule binding; calcium channel activity; beta-tubulin binding; actin binding; protein kinase binding; actin filament binding; calmodulin binding; protein binding; protein kinase C binding; osmosensor activity; cation channel activity; SH2 domain binding; ATP binding; alpha-tubulin binding

Biological Process: intercellular junction assembly; actin filament organization; regulation of response to osmotic stress; osmosensory signaling pathway; cellular calcium ion homeostasis; vasopressin secretion; elevation of cytosolic calcium ion concentration; positive regulation of microtubule depolymerization; hyperosmotic salinity response; response to mechanical stimulus; calcium ion transport; actin cytoskeleton reorganization; cell volume homeostasis; cortical microtubule organization and biogenesis; transmembrane transport; microtubule polymerization

Disease: Brachyolmia Type 3; Scapuloperoneal Spinal Muscular Atrophy; Hereditary Motor And Sensory Neuropathy, Type Iic; Spondyloepiphyseal Dysplasia, Maroteaux Type; Sodium Serum Level Quantitative Trait Locus 1; Parastremmatic Dwarfism; Spinal Muscular Atrophy, Distal, Congenital Nonprogressive; Digital Arthropathy-brachydactyly, Familial; Spondylometaphyseal Dysplasia, Kozlowski Type; Metatropic Dysplasia
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 Research Articles on TRPV4    1. data strongly support that up-regulation of FST in chondrocytes by skeletal dysplasia-inducing TRPV4 mutations contributes to disease pathogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TRPV4 antibodyDiseases associated with anti-TRPV4 antibody
 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >121 publications with TRPV4 and Nervous System Diseases
 Pain Antibodies  >120 publications with TRPV4 and Pain
 Inflammation Antibodies  >67 publications with TRPV4 and Inflammation
 Hypertension Antibodies  >48 publications with TRPV4 and Hypertension
 Hyperalgesia Antibodies  >46 publications with TRPV4 and Hyperalgesia
 Disease Models, Animal Antibodies  >39 publications with TRPV4 and Disease Models, Animal
 Bone Diseases Antibodies  >31 publications with TRPV4 and Bone Diseases
 Muscular Atrophy, Spinal Antibodies  >22 publications with TRPV4 and Muscular Atrophy, Spinal
 SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY Antibodies  >22 publications with TRPV4 and SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY
 Charcot-Marie-Tooth Disease Antibodies  >19 publications with TRPV4 and Charcot-Marie-Tooth Disease
Organs/Tissues associated with anti-TRPV4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with TRPV4 and Brain
 Kidney Antibodies  >72 publications with TRPV4 and Kidney
 Lung Antibodies  >58 publications with TRPV4 and Lung
 Bone Antibodies  >46 publications with TRPV4 and Bone
 Skin Antibodies  >46 publications with TRPV4 and Skin
 Heart Antibodies  >41 publications with TRPV4 and Heart
 Liver Antibodies  >20 publications with TRPV4 and Liver
 Intestine Antibodies  >18 publications with TRPV4 and Intestine
 Connective Tissue Antibodies  >12 publications with TRPV4 and Connective Tissue
 Mouth Antibodies  >11 publications with TRPV4 and Mouth
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