AAH25957.1
[Other Products]
UniProt Related Accession #
NCBI Official Full Name
Transmembrane emp24 domain trafficking protein 2
NCBI Official Synonym Full Names
transmembrane emp24 domain trafficking protein 2
NCBI Protein Information
transmembrane emp24 domain-containing protein 2; p24beta1; membrane protein p24A; p24 family protein beta-1; coated vesicle membrane protein
UniProt Protein Name
Transmembrane emp24 domain-containing protein 2
UniProt Synonym Protein Names
Membrane protein p24A; p24; p24 family protein beta-1; p24beta1
UniProt Synonym Gene Names
UniProt Entry Name
TMED2_HUMAN
UniProt Comments for TMED2
TMED2: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. Belongs to the EMP24/GP25L family.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: COPI coated vesicle membrane; Golgi apparatus; COPI-coated vesicle; endoplasmic reticulum membrane; zymogen granule membrane; ER-Golgi intermediate compartment membrane; intracellular membrane-bound organelle; endoplasmic reticulum; ER-Golgi intermediate compartment; integral to membrane
Molecular Function: protein binding
Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; COPI coating of Golgi vesicle; embryonic morphogenesis; Golgi organization and biogenesis; maternal placenta development
Research Articles on TMED2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-TMED2 antibody
Pathways associated with anti-TMED2 antibody
Diseases associated with anti-TMED2 antibody
Organs/Tissues associated with anti-TMED2 antibody
|