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anti-TNFRSF1A antibody :: Rabbit anti-Human tumor necrosis factor receptor superfamily, member 1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712861 anti-TNFRSF1A antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human tumor necrosis factor receptor superfamily, member 1A polyclonal Antibody

 Product Synonym Names    tumor necrosis factor receptor superfamily; member 1A; TNFRSF1A; CD120a; FPF; MGC19588; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; p55; p55-R; p60
 Product Gene Name   

anti-TNFRSF1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614810
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human TNFR1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12746 / sc-1069 / sc-1067 / sc-1068 / sc-31349 / sc-31350 / sc-31351 / sc-7895
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TNFRSF1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TNFRSF1A antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TNFRSF1A. It may not necessarily be applicable to this product.
 NCBI GI #    4507575
 NCBI GeneID    7132
 NCBI Accession #    NP_001056.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001065.3 [Other Products]
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 UniProt Secondary Accession #    Q9UCA4; A8K4X3; B2RDE4; B3KPQ1; B4DQB7; B4E309; B5M0B5; D3DUR1 [Other Products]
 UniProt Related Accession #    P19438 [Other Products]
 Molecular Weight    24,194 Da [Similar Products]
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 1A
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 1A
 NCBI Official Symbol    TNFRSF1A [Similar Products]
 NCBI Official Synonym Symbols   
FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 1A
 UniProt Synonym Protein Names   
Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD_antigen: CD120aCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF1A [Similar Products]
 UniProt Synonym Gene Names    TNFAR; TNFR1; TNF-R1; TNF-RI; TNFR-I; TBPI [Similar Products]
 UniProt Entry Name    TNR1A_HUMAN
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 NCBI Summary for TNFRSF1A    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFRSF1A    TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; extracellular region; cytosol; lipid raft; Golgi membrane; axon; plasma membrane; synapse; nucleus; receptor complex

Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding

Biological Process: response to alkaloid; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; viral reproduction; protein heterooligomerization; cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; response to amino acid stimulus; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; negative regulation of inflammatory response; defense response to bacterium; negative regulation of interleukin-6 production; response to wounding; response to hypoxia; tetrapyrrole metabolic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of apoptosis; positive regulation of inflammatory response

Disease: Periodic Fever, Familial, Autosomal Dominant; Multiple Sclerosis, Susceptibility To, 5
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 Research Articles on TNFRSF1A    1. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF1A antibodyPathways associated with anti-TNFRSF1A antibody
 Reference Product  PubMed Publications
 TNF antibody  >417 publications with TNFRSF1A and TNF
 FADD antibody  >15 publications with TNFRSF1A and FADD
 TRADD antibody  >14 publications with TNFRSF1A and TRADD
 TRAF2 antibody  >13 publications with TNFRSF1A and TRAF2
 IKBKB antibody  >12 publications with TNFRSF1A and IKBKB
 RIPK1 antibody  >11 publications with TNFRSF1A and RIPK1
 LTA antibody  >7 publications with TNFRSF1A and LTA
 TRAF1 antibody  >3 publications with TNFRSF1A and TRAF1
 BIRC2 antibody  >2 publications with TNFRSF1A and BIRC2
 Products by Pathway  Pathway Diagram
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 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
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 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-TNFRSF1A antibodyOrgans/Tissues associated with anti-TNFRSF1A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >597 publications with TNFRSF1A and Necrosis
 Inflammation Antibodies  >201 publications with TNFRSF1A and Inflammation
 Fever Antibodies  >156 publications with TNFRSF1A and Fever
 Autoimmune Diseases Antibodies  >93 publications with TNFRSF1A and Autoimmune Diseases
 Pain Antibodies  >66 publications with TNFRSF1A and Pain
 Cardiovascular Diseases Antibodies  >64 publications with TNFRSF1A and Cardiovascular Diseases
 Heart Diseases Antibodies  >38 publications with TNFRSF1A and Heart Diseases
 Multiple Sclerosis Antibodies  >34 publications with TNFRSF1A and Multiple Sclerosis
 Lung Diseases Antibodies  >32 publications with TNFRSF1A and Lung Diseases
 Liver Diseases Antibodies  >30 publications with TNFRSF1A and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >209 publications with TNFRSF1A and Blood
 Brain Antibodies  >58 publications with TNFRSF1A and Brain
 Liver Antibodies  >51 publications with TNFRSF1A and Liver
 Skin Antibodies  >49 publications with TNFRSF1A and Skin
 Vascular Antibodies  >47 publications with TNFRSF1A and Vascular
 Muscle Antibodies  >44 publications with TNFRSF1A and Muscle
 Bone Antibodies  >44 publications with TNFRSF1A and Bone
 Lung Antibodies  >37 publications with TNFRSF1A and Lung
 Bone Marrow Antibodies  >31 publications with TNFRSF1A and Bone Marrow
 Nerve Antibodies  >30 publications with TNFRSF1A and Nerve
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