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anti-PLAUR antibody :: Rabbit anti-Human uPA Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175403
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

uPA Receptor (PLAUR), Polyclonal Antibody

 Also Known As   

Anti-uPA Receptor antibody

 Product Synonym Names    Urokinase plasminogen activator surface receptor(U-PAR/uPAR); plasminogen activator, urokinase receptor; CD 87 antibody; CD87 antibody; CD87 antigen antibody; MO 3 antibody; MO3 antibody; Monocyte activation antigen Mo3 antibody; Plasminogen activator urokinase receptor antibody; PLAUR antibody; U PAR antibody; u plasminogen activator receptor antibody; U-PAR antibody; UPA receptor antibody; UPAR antibody; UPAR_HUMAN antibody; Urinary plasminogen activator receptor antibody; URKR antibody; Urokinase plasminogen activator receptor antibody; Urokinase plasminogen activator surface receptor antibody
 Product Gene Name   

anti-PLAUR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173391
 3D Structure    ModBase 3D Structure for Q03405
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human uPA Receptor (293-304aa CNHPDLDVQYRS).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PLAUR antibody

   Description: Rabbit IgG polyclonal antibody for Urokinase plasminogen activator surface receptor(PLAUR) detection. Tested with WB, IHC-P in Human.
Background: PLAUR(PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol(GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.
 Applications Tested/Suitable for anti-PLAUR antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Testing Data of anti-PLAUR antibody    anti-PLAUR antibody Testing Data image
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 Testing Data #2 of anti-PLAUR antibody    anti-PLAUR antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.
 NCBI GI #    465003
 NCBI GeneID    5329
 NCBI Accession #    Q03405.1 [Other Products]
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 UniProt Primary Accession #    Q03405 [Other Products]
 UniProt Secondary Accession #    Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0; A8K409 [Other Products]
 UniProt Related Accession #    Q03405 [Other Products]
 Molecular Weight    32,016 Da
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 NCBI Official Full Name    Urokinase plasminogen activator surface receptor
 NCBI Official Synonym Full Names    plasminogen activator, urokinase receptor
 NCBI Official Symbol    PLAUR [Similar Products]
 NCBI Official Synonym Symbols   
CD87; UPAR; URKR; U-PAR
[Similar Products]
 NCBI Protein Information    urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor
 UniProt Protein Name    Urokinase plasminogen activator surface receptor
 UniProt Synonym Protein Names   
Monocyte activation antigen Mo3; CD_antigen: CD87
 Protein Family    Urokinase plasminogen activator surface receptor
 UniProt Gene Name    PLAUR [Similar Products]
 UniProt Synonym Gene Names    MO3; UPAR; U-PAR; uPAR [Similar Products]
 UniProt Entry Name    UPAR_HUMAN
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 NCBI Summary for PLAUR    This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLAUR    uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane

Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; regulation of proteolysis; attachment of GPI anchor to protein; C-terminal protein lipidation; post-translational protein modification; cell motility; chemotaxis; signal transduction; blood coagulation
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 Research Articles on PLAUR    1. The uPAR-C5aR axis, via the underlying NFkappaB transcriptional program, controls osteogenic differentiation with functional impact on vascular calcification in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLAUR antibodyDiseases associated with anti-PLAUR antibody
 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Attachment Of GPI Anchor To UPAR Pathway antibodies  Attachment Of GPI Anchor To UPAR Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >314 publications with PLAUR and Carcinoma
 Neoplasm Invasiveness Antibodies  >262 publications with PLAUR and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >240 publications with PLAUR and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >165 publications with PLAUR and Breast Neoplasms
 Inflammation Antibodies  >113 publications with PLAUR and Inflammation
 Lung Diseases Antibodies  >90 publications with PLAUR and Lung Diseases
 Nervous System Diseases Antibodies  >83 publications with PLAUR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >83 publications with PLAUR and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >76 publications with PLAUR and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >75 publications with PLAUR and Neoplasms, Experimental
Organs/Tissues associated with anti-PLAUR antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >506 publications with PLAUR and Blood
 Vascular Antibodies  >302 publications with PLAUR and Vascular
 Lung Antibodies  >147 publications with PLAUR and Lung
 Muscle Antibodies  >98 publications with PLAUR and Muscle
 Brain Antibodies  >86 publications with PLAUR and Brain
 Liver Antibodies  >83 publications with PLAUR and Liver
 Embryonic Tissue Antibodies  >80 publications with PLAUR and Embryonic Tissue
 Bone Antibodies  >80 publications with PLAUR and Bone
 Kidney Antibodies  >76 publications with PLAUR and Kidney
 Skin Antibodies  >65 publications with PLAUR and Skin
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