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anti-USP1 antibody :: Rabbit ubiquitin specific peptidase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719158 anti-USP1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ubiquitin specific peptidase 1 (USP1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human ubiquitin specific peptidase 1 polyclonal Antibody

 Product Synonym Names    ubiquitin specific peptidase 1; USP1; UBP
 Product Gene Name   

anti-USP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603478
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human USP1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104734 / sc-104735 / sc-135222
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-USP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-USP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for USP1. It may not necessarily be applicable to this product.
 NCBI GI #    29791616
 NCBI GeneID    7398
 NCBI Accession #    AAH50525.1 [Other Products]
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 UniProt Secondary Accession #    Q05BX7; Q59H66; Q9UFR0; Q9UNJ3; A0PJ95; D3DQ57 [Other Products]
 UniProt Related Accession #    O94782 [Other Products]
 Molecular Weight    88,207 Da [Similar Products]
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 NCBI Official Full Name    Ubiquitin specific peptidase 1
 NCBI Official Synonym Full Names    ubiquitin specific peptidase 1
 NCBI Official Symbol    USP1 [Similar Products]
 NCBI Official Synonym Symbols   
UBP
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase 1; hUBP; ubiquitin thioesterase 1; deubiquitinating enzyme 1; ubiquitin thiolesterase 1; ubiquitin specific protease 1; ubiquitin carboxyl terminal hydrolase 1; ubiquitin specific processing protease 1; ubiquitin-specific-processing protease 1
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase 1
 UniProt Synonym Protein Names   
Deubiquitinating enzyme 1; hUBP; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1
 Protein Family    UDP-sugar pyrophosphorylase
 UniProt Gene Name    USP1 [Similar Products]
 UniProt Synonym Gene Names    hUBP [Similar Products]
 UniProt Entry Name    UBP1_HUMAN
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 NCBI Summary for USP1    This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for USP1    USP1: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Interacts with FANCD2 and PCNA. Interacts with WDR48. Down-regulated following DNA damage. Belongs to the peptidase C19 family.

Protein type: EC 3.4.19.12; Ubiquitin conjugating system; Ubiquitin-specific protease; Protease

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: regulation of DNA repair; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA repair; skeletal development; response to UV
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 Research Articles on USP1    1. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1, USP12 and USP46.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-USP1 antibodyPathways associated with anti-USP1 antibody
 Reference Product  PubMed Publications
 PCNA antibody  >25 publications with USP1 and PCNA
 FANCD2 antibody  >17 publications with USP1 and FANCD2
 ATAD5 antibody  >3 publications with USP1 and ATAD5
 FANCI antibody  >3 publications with USP1 and FANCI
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Regulation Of The Fanconi Anemia Pathway antibodies  Regulation Of The Fanconi Anemia Pathway Diagram
Diseases associated with anti-USP1 antibodyOrgans/Tissues associated with anti-USP1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >22 publications with USP1 and Anemia
 Infertility, Female Antibodies  >2 publications with USP1 and Infertility, Female
 Infertility, Male Antibodies  >2 publications with USP1 and Infertility, Male
 Breast Neoplasms Antibodies  >1 publications with USP1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with USP1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with USP1 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with USP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with USP1 and Lung
 Skin Antibodies  >4 publications with USP1 and Skin
 Bone Marrow Antibodies  >3 publications with USP1 and Bone Marrow
 Bone Antibodies  >3 publications with USP1 and Bone
 Blood Antibodies  >2 publications with USP1 and Blood
 Embryonic Tissue Antibodies  >2 publications with USP1 and Embryonic Tissue
 Liver Antibodies  >1 publications with USP1 and Liver
 Placenta Antibodies  >1 publications with USP1 and Placenta
 Nerve Antibodies  >1 publications with USP1 and Nerve
 Prostate Antibodies  >1 publications with USP1 and Prostate
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