AAI43350.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ubiquitin specific peptidase 48
NCBI Official Synonym Full Names
ubiquitin specific peptidase 48
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 48; ubiquitin thioesterase 48; deubiquitinating enzyme 48; ubiquitin thiolesterase 48; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin-specific-processing protease 48
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 48
UniProt Synonym Protein Names
Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48
UniProt Synonym Gene Names
UniProt Entry Name
UBP48_HUMAN
NCBI Summary for USP48
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for USP48
USP48: Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Belongs to the peptidase C19 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Ubiquitin-specific protease; Ubiquitin conjugating system; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleoplasm; mitochondrion; cytoplasm
Molecular Function: cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination
Research Articles on USP48
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with anti-USP48 antibody
Organs/Tissues associated with anti-USP48 antibody
|