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anti-CRK antibody :: Rabbit v-crk sarcoma virus CT10 oncogene homolog Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716944 anti-CRK antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

v-crk sarcoma virus CT10 oncogene homolog, Polyclonal Antibody

 Also Known As   

Rabbit anti-human v-crk sarcoma virus CT10 oncogene homolog (avian) polyclonal Antibody

 Product Synonym Names    v-crk sarcoma virus CT10 oncogene homolog (avian); CRK; CRKII
 Product Gene Name   

anti-CRK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164762
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CRK
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17989 / sc-23775 / sc-9004 / sc-289
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CRK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CRK antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CRK. It may not necessarily be applicable to this product.
 NCBI GI #    45708482
 NCBI GeneID    1398
 NCBI Accession #    AAH01718.1 [Other Products]
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 UniProt Secondary Accession #    Q96GA9; Q96HJ0; A8MWE8; B0LPE8; D3DTH6 [Other Products]
 UniProt Related Accession #    P46108 [Other Products]
 Molecular Weight    22,906 Da [Similar Products]
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 NCBI Official Full Name    V-crk sarcoma virus CT10 oncogene homolog (avian)
 NCBI Official Synonym Full Names    v-crk avian sarcoma virus CT10 oncogene homolog
 NCBI Official Symbol    CRK [Similar Products]
 NCBI Official Synonym Symbols   
p38; CRKII
[Similar Products]
 NCBI Protein Information    adapter molecule crk; proto-oncogene c-Crk
 UniProt Protein Name    Adapter molecule crk
 UniProt Synonym Protein Names   
Proto-oncogene c-Crk; p38
 Protein Family    Adapter molecule
 UniProt Gene Name    CRK [Similar Products]
 UniProt Entry Name    CRK_HUMAN
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 NCBI Summary for CRK    This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CRK    CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol; actin cytoskeleton

Molecular Function: protein phosphorylated amino acid binding; protein binding; ephrin receptor binding; SH3/SH2 adaptor activity; SH2 domain binding

Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of Rac protein signal transduction; platelet activation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; insulin receptor signaling pathway; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on CRK    1. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRK antibodyPathways associated with anti-CRK antibody
 Reference Product  PubMed Publications
 BCAR1 antibody  >390 publications with CRK and BCAR1
 PTK2 antibody  >155 publications with CRK and PTK2
 CBL antibody  >108 publications with CRK and CBL
 PXN antibody  >102 publications with CRK and PXN
 DOCK1 antibody  >34 publications with CRK and DOCK1
 ABL1 antibody  >7 publications with CRK and ABL1
 RAPGEF1 antibody  >4 publications with CRK and RAPGEF1
 CBLB antibody  >3 publications with CRK and CBLB
 PIK3R1 antibody  >2 publications with CRK and PIK3R1
 MAP4K1 antibody  >1 publications with CRK and MAP4K1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-CRK antibodyOrgans/Tissues associated with anti-CRK antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >48 publications with CRK and Lung Neoplasms
 Disease Models, Animal Antibodies  >35 publications with CRK and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >29 publications with CRK and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >25 publications with CRK and Adenocarcinoma
 Inflammation Antibodies  >23 publications with CRK and Inflammation
 Brain Diseases Antibodies  >17 publications with CRK and Brain Diseases
 Heart Diseases Antibodies  >16 publications with CRK and Heart Diseases
 Kidney Diseases Antibodies  >10 publications with CRK and Kidney Diseases
 Liver Neoplasms Antibodies  >9 publications with CRK and Liver Neoplasms
 Necrosis Antibodies  >9 publications with CRK and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >150 publications with CRK and Blood
 Vascular Antibodies  >89 publications with CRK and Vascular
 Muscle Antibodies  >87 publications with CRK and Muscle
 Brain Antibodies  >84 publications with CRK and Brain
 Lung Antibodies  >74 publications with CRK and Lung
 Bone Antibodies  >49 publications with CRK and Bone
 Kidney Antibodies  >40 publications with CRK and Kidney
 Heart Antibodies  >35 publications with CRK and Heart
 Embryonic Tissue Antibodies  >33 publications with CRK and Embryonic Tissue
 Bone Marrow Antibodies  >28 publications with CRK and Bone Marrow
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