View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-CRK antibody :: Rabbit v-crk sarcoma virus CT10 oncogene homolog Polyclonal Antibody Catalog # MBS716944 Unit / Price 0.1 mL / $495 +1 FREE 8GB USB 5x0.1 mL / $2,225 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name v-crk sarcoma virus CT10 oncogene homolog, Polyclonal Antibody Full Product Name Rabbit anti-human v-crk sarcoma virus CT10 oncogene homolog (avian) polyclonal Antibody Product Synonym Names v-crk sarcoma virus CT10 oncogene homolog (avian); CRK; CRKII Product Gene Name anti-CRK antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 164762 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Purity/Purification Antigen Affinity Purified Immunogen Human CRK Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles. Santa Cruz Alternative Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17989 / sc-23775 / sc-9004 / sc-289 ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-CRK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for anti-CRK antibody ELISA (EIA), Western Blot (WB) TOP NCBI/Uniprot data below describe general gene information for CRK. It may not necessarily be applicable to this product. NCBI GI # 45708482 NCBI GeneID 1398 NCBI Accession # AAH01718.1 [Other Products] UniProt Secondary Accession # Q96GA9; Q96HJ0; A8MWE8; B0LPE8; D3DTH6[Other Products] UniProt Related Accession # P46108[Other Products] Molecular Weight 22,906 Da[Similar Products] TOP NCBI Official Full Name V-crk sarcoma virus CT10 oncogene homolog (avian) NCBI Official Synonym Full Names v-crk avian sarcoma virus CT10 oncogene homolog NCBI Official Symbol CRK [Similar Products] NCBI Official Synonym Symbols p38; CRKII [Similar Products] NCBI Protein Information adapter molecule crk; proto-oncogene c-Crk UniProt Protein Name Adapter molecule crk UniProt Synonym Protein Names Proto-oncogene c-Crk; p38 Protein Family Adapter molecule UniProt Gene Name CRK [Similar Products] UniProt Entry Name CRK_HUMAN TOP NCBI Summary for CRK This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] TOP UniProt Comments for CRK CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex.Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 17p13.3Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol; actin cytoskeletonMolecular Function: protein phosphorylated amino acid binding; protein binding; ephrin receptor binding; SH3/SH2 adaptor activity; SH2 domain bindingBiological Process: regulation of transcription from RNA polymerase II promoter; regulation of Rac protein signal transduction; platelet activation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; insulin receptor signaling pathway; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway Research Articles on CRK 1. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-CRK antibody Reference Product PubMed Publications BCAR1 antibody >390 publications with CRK and BCAR1 PTK2 antibody >155 publications with CRK and PTK2 CBL antibody >108 publications with CRK and CBL PXN antibody >102 publications with CRK and PXN DOCK1 antibody >34 publications with CRK and DOCK1 ABL1 antibody >7 publications with CRK and ABL1 RAPGEF1 antibody >4 publications with CRK and RAPGEF1 CBLB antibody >3 publications with CRK and CBLB PIK3R1 antibody >2 publications with CRK and PIK3R1 MAP4K1 antibody >1 publications with CRK and MAP4K1 Pathways associated with anti-CRK antibody Products by Pathway Pathway Diagram ARMS-mediated Activation Pathway antibodies ARMS-mediated Activation Pathway Diagram Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram Bacterial Invasion Of Epithelial Cells Pathway antibodies Bacterial Invasion Of Epithelial Cells Pathway Diagram Bacterial Invasion Of Epithelial Cells Pathway antibodies Bacterial Invasion Of Epithelial Cells Pathway Diagram CXCR4-mediated Signaling Events Pathway antibodies CXCR4-mediated Signaling Events Pathway Diagram Chemokine Signaling Pathway antibodies Chemokine Signaling Pathway Diagram Chemokine Signaling Pathway antibodies Chemokine Signaling Pathway Diagram Chronic Myeloid Leukemia Pathway antibodies Chronic Myeloid Leukemia Pathway Diagram Chronic Myeloid Leukemia Pathway antibodies Chronic Myeloid Leukemia Pathway Diagram Diseases associated with anti-CRK antibody Disease Name Pubmed Publications Lung Neoplasms Antibodies >48 publications with CRK and Lung Neoplasms Disease Models, Animal Antibodies >35 publications with CRK and Disease Models, Animal Cardiovascular Diseases Antibodies >29 publications with CRK and Cardiovascular Diseases Adenocarcinoma Antibodies >25 publications with CRK and Adenocarcinoma Inflammation Antibodies >23 publications with CRK and Inflammation Brain Diseases Antibodies >17 publications with CRK and Brain Diseases Heart Diseases Antibodies >16 publications with CRK and Heart Diseases Kidney Diseases Antibodies >10 publications with CRK and Kidney Diseases Liver Neoplasms Antibodies >9 publications with CRK and Liver Neoplasms Necrosis Antibodies >9 publications with CRK and Necrosis Organs/Tissues associated with anti-CRK antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >150 publications with CRK and Blood Vascular Antibodies >89 publications with CRK and Vascular Muscle Antibodies >87 publications with CRK and Muscle Brain Antibodies >84 publications with CRK and Brain Lung Antibodies >74 publications with CRK and Lung Bone Antibodies >49 publications with CRK and Bone Kidney Antibodies >40 publications with CRK and Kidney Heart Antibodies >35 publications with CRK and Heart Embryonic Tissue Antibodies >33 publications with CRK and Embryonic Tissue Bone Marrow Antibodies >28 publications with CRK and Bone Marrow TOP © 2006-24 MyBioSource.com. 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