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anti-RALB antibody :: Rabbit v-ral simian leukemia viral oncogene homolog B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712220 anti-RALB antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

v-ral simian leukemia viral oncogene homolog B (RALB), Polyclonal Antibody

 Also Known As   

Rabbit anti-human v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) polyclonal Antibody

 Product Synonym Names    v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein);
 Product Gene Name   

anti-RALB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179551
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human RALB
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1531
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RALB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RALB antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RALB. It may not necessarily be applicable to this product.
 NCBI GI #    119615648
 NCBI GeneID    5899
 NCBI Accession #    EAW95242.1 [Other Products]
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 UniProt Secondary Accession #    Q53T32; Q6ZS74; B4E040 [Other Products]
 UniProt Related Accession #    P11234 [Other Products]
 Molecular Weight    25,710 Da [Similar Products]
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 NCBI Official Full Name    v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein), isoform CRA_b
 NCBI Official Synonym Full Names    v-ral simian leukemia viral oncogene homolog B
 NCBI Official Symbol    RALB [Similar Products]
 NCBI Protein Information    ras-related protein Ral-B; RAS-like protein B; ras related GTP binding protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
 UniProt Protein Name    Ras-related protein Ral-B
 Protein Family    Ras-related protein
 UniProt Gene Name    RALB [Similar Products]
 UniProt Entry Name    RALB_HUMAN
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 NCBI Summary for RALB    This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RALB    RALB: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: plasma membrane; exocyst; autophagic vacuole; midbody

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; ubiquitin protein ligase binding; ATPase binding

Biological Process: regulation of exocyst localization; positive regulation of protein binding; nerve growth factor receptor signaling pathway; apoptosis; metabolic process; regulation of exocyst assembly; Ras protein signal transduction; cytokinesis; positive regulation of protein amino acid phosphorylation; cellular response to starvation; signal transduction; negative regulation of protein binding
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 Research Articles on RALB    1. Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RALB antibodyPathways associated with anti-RALB antibody
 Reference Product  PubMed Publications
 RALA antibody  >96 publications with RALB and RALA
 RALGDS antibody  >26 publications with RALB and RALGDS
 RALBP1 antibody  >23 publications with RALB and RALBP1
 EXOC2 antibody  >8 publications with RALB and EXOC2
 EXOC8 antibody  >6 publications with RALB and EXOC8
 PLD1 antibody  >4 publications with RALB and PLD1
 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pancreatic Cancer Pathway antibodies  Pancreatic Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-RALB antibodyOrgans/Tissues associated with anti-RALB antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >19 publications with RALB and Carcinoma
 Pancreatic Neoplasms Antibodies  >9 publications with RALB and Pancreatic Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with RALB and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >8 publications with RALB and Lung Neoplasms
 Adenocarcinoma Antibodies  >6 publications with RALB and Adenocarcinoma
 Urinary Bladder Neoplasms Antibodies  >6 publications with RALB and Urinary Bladder Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with RALB and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with RALB and Inflammation
 Prostatic Neoplasms Antibodies  >3 publications with RALB and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >3 publications with RALB and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with RALB and Blood
 Brain Antibodies  >13 publications with RALB and Brain
 Lung Antibodies  >12 publications with RALB and Lung
 Kidney Antibodies  >8 publications with RALB and Kidney
 Muscle Antibodies  >8 publications with RALB and Muscle
 Bladder Antibodies  >6 publications with RALB and Bladder
 Prostate Antibodies  >5 publications with RALB and Prostate
 Embryonic Tissue Antibodies  >5 publications with RALB and Embryonic Tissue
 Liver Antibodies  >3 publications with RALB and Liver
 Skin Antibodies  >3 publications with RALB and Skin
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