Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow VWF rightarrow Polyclonal VWF  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • T-Box Protein 3 (TBX3) Recombinant Protein
 • SEPT2 Antibody
 • CPT1A Antibody
 • (R)-mandelonitrile lyase 1, partial (MDL1) Recombinant Protein
 • 3-oxoacid CoA transferase 1 (OXCT1) Antibody
 • Histone-Binding Protein RBBP4 (RBBP4) ELISA Kit
 • IL2 Antibody
 • solute carrier family 19 (folate transporter) , member 1 (Sl... ELISA Kit
 • YWHAZ Antibody
 • LCP1 Antibody
 • Chromobox protein homolog 8 (CBX8) Antibody
 • ELOVL4 Antibody
 • Na+ K+ ATPase alpha 1 (atp1a1) Antibody
 • T cells (pan) Antibody
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-VWF antibody :: Goat von Willebrand Factor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512178 anti-VWF antibody
Unit / Price
0.1 mg  /  $340 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

von Willebrand Factor (VWF), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-human von Willebrand Factor, Biotinylated Affinity-Purified IgG

 Product Synonym Names    von Willebrand Factor, human
 Product Gene Name   

anti-VWF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 27; NC_006609.2 (41865033..42002564)
 3D Structure    ModBase 3D Structure for Q28295
Section Bar
 Clonality    Polyclonal
 Host    Goat
Section Bar
 Specificity    Prior to conjugation, this antibody was specific for vWF as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Affinity purified, Biotinylated IgG.
Vial containing mL of affinity-purified IgG conjugated to biotin. Total protein is 0.1 mg.
 Form/Format    APIgG-biotin conjugate as a clear, colourless liquid.
 Concentration    APIgG-biotin concentration is 1 mg/mL, determined by absorbance using an extinction coefficient (E1%280) of 14. (lot specific)
Section Bar
 Immunogen    Human vWF purified from plasma.
 Description    Vial containing 0.1mL of affinity-purified IgG conjugated to biotin. Total protein is 0.1 mg
 Buffer    Phosphate-buffered saline containing 1 mg/mL bovine albumin and 0.1% sodium azide (w/v), pH 7.4.
 Incorporation of Biotin    7.82 moles biotin per mole IgG as determined by HABA assay.
Section Bar
 Preparation and Storage    Store at 2 degree C to 8 degree C.
 Other Notes    Small volumes of anti-VWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for anti-VWF antibody

   von Willebrand Factor (vWF, also previously referred to as Factor VIII related antigen) is a large adhesive protein produced in endothelial cells and megakaryocytes. There are two critical functions of vWF, the first being its involvement in the process of platelet adhesion and aggregation through interaction with platelet receptor glycoprotein Ib, the second being the binding and stabilization of Factor VIII (antihemophilic factor) for secretion and transport in plasma. The vWF precursor protein is synthesized with a 95,000 dalton propeptide (also known as vWF antigen-II), believed to be involved in the intracellular multimerization of the vWF subunits. The mature vWF multimers are then packed into storage organelles within the cell (Weibel-Palade bodies) after which the propeptide is cleaved and released. vWF circulates as multimers of disulphide linked 220,000 dalton subunits and the molecular weight of these multimers ranges from 0.5- 20 million daltons. The plasma concentration of vWF is typically 10 ug/mL, but increased levels are often observed in pregnancy and other conditions of physiological stress. von Willebrand's disease (vWD) is perhaps the most common inherited bleeding disorder in humans and is the result of either quantitative deficiencies of vWF (vWD Types I & III), or one of a number of qualitative disorders of vWF structure and function (vWD Type II).
 Applications Tested/Suitable for anti-VWF antibody   

Suitable as a source of biotinylated antibodies to vWF.

 Application Notes for anti-VWF antibody    Related Products:
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    50950127
 NCBI GeneID    399544
 NCBI Accession #    NP_001002932.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002932.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q28295 [Other Products]
 UniProt Secondary Accession #    Q28311; Q9TSI4 [Other Products]
 UniProt Related Accession #    Q28295 [Other Products]
 Molecular Weight    309533 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    von Willebrand factor
 UniProt Protein Name    von Willebrand factor
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF [Similar Products]
 UniProt Entry Name    VWF_CANFA
Section Bar
 UniProt Comments for VWF    Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

Subunit structure: Multimeric. Interacts with F8. Ref.2

Subcellular location: Secreted. Secreted › extracellular space › extracellular matrix. Note: Localized to storage granules. Ref.2

Tissue specificity: Plasma.

Domain: The propeptide is required for multimerization of vWF and for its targeting to storage granules.

Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds

By similarity.N- and O-glycosylated

Involvement in disease: Note=Defects in VWF are the cause of von Willebrand disease (VWD) in the Scottish Terrier. VWD is characterized by frequent bleeding. Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. Ref.4

Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 4 TIL (trypsin inhibitory-like) domains.Contains 3 VWFA domains.Contains 3 VWFC domains.Contains 4 VWFD domains.
Table BarTOPTable Bar

Product References and Citations for anti-VWF antibody

   1. Montgomery RR, Coller BS, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 134-168, J.B. Lippincott Co., Philadelphia PA, USA, 1994.
2. Sadler JE; von Willebrand Factor (Minireview); JBC 266:34, pp 22777- 22780, 1991.
Section Bar
 Research Articles on VWF    1. the CD-31 and vonWillebrand factor (vWF) expressions and the cell morphological alterations ofarachnoid villus endothelium in different stages of animal hydrocephalus
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-VWF antibodyDiseases associated with anti-VWF antibody
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 von Willebrand Diseases Antibodies  >1739 publications with VWF and von Willebrand Diseases
 Cardiovascular Diseases Antibodies  >1608 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1170 publications with VWF and Thrombosis
 Inflammation Antibodies  >432 publications with VWF and Inflammation
 Purpura Antibodies  >397 publications with VWF and Purpura
 Thrombophilia Antibodies  >392 publications with VWF and Thrombophilia
 Neoplasms Antibodies  >374 publications with VWF and Neoplasms
 Coronary Disease Antibodies  >278 publications with VWF and Coronary Disease
 Kidney Diseases Antibodies  >274 publications with VWF and Kidney Diseases
 Arteriosclerosis Antibodies  >243 publications with VWF and Arteriosclerosis
Organs/Tissues associated with anti-VWF antibody
 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >660 publications with VWF and Artery
 Muscle Antibodies  >281 publications with VWF and Muscle
 Kidney Antibodies  >226 publications with VWF and Kidney
 Liver Antibodies  >206 publications with VWF and Liver
 Brain Antibodies  >187 publications with VWF and Brain
 Eye Antibodies  >45 publications with VWF and Eye
 Female Genital Antibodies  >36 publications with VWF and Female Genital
 Testis Antibodies  >3 publications with VWF and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions