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anti-VWF antibody :: Sheep von Willebrand Factor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512181 anti-VWF antibody
Unit / Price
5 mg  /  $305 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

von Willebrand Factor (VWF), Polyclonal Antibody

★Popular Item★
 Also Known As   

Sheep anti-rat von Willebrand Factor, Whole IgG from antiserum

 Product Synonym Names    von Willebrand Factor, rat
 Product Gene Name   

anti-VWF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 27; NC_006609.2 (41865033..42002564)
 3D Structure    ModBase 3D Structure for Q28295
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 Clonality    Polyclonal
 Host    Sheep
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 Specificity    This antibody is specific for rat vWF as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Purified IgG.
 Form/Format    Whole IgG, clear liquid.
 Concentration    IgG concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 13.4. (lot specific)
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 Note    Vial containing ml of whole IgG representing approximately 1 ml of antiserum. Total protein is 5 mg.
 Immunogen    Rat vWF purified from plasma.
 Buffer    10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol.
 Neutralizing Activity    Not determined
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 Preparation and Storage    Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.
 Other Notes    Small volumes of anti-VWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VWF antibody

   von Willebrand Factor (vWF, also previously referred to as Factor VIII related antigen) is a large adhesive protein produced in endothelial cells and megakaryocytes. There are two critical functions of vWF, the first being its involvement in the process of platelet adhesion and aggregation through interaction with platelet receptor glycoprotein Ib, the second being the binding and stabilization of Factor VIII (antihemophilic factor) for secretion and transport in plasma. The vWF precursor protein is synthesized with a 95,000 dalton propeptide (also known as vWF antigen-II), believed to be involved in the intracellular multimerization of the vWF subunits. The mature vWF multimers are then packed into storage organelles within the cell (Weibel-Palade bodies) after which the propeptide is cleaved and released. vWF circulates as multimers of disulphide linked 220,000 dalton subunits and the molecular weight of these multimers ranges from 0.5- 20 million daltons. The concentration of vWF in human plasma is typically 10 ug/ml, but increased levels are often observed in pregnancy and other conditions of physiological stress. von Willebrand's disease (vWD) is perhaps the most common inherited bleeding disorder in humans and is the result of either quantitative deficiencies of vWF (vWD Types I & III), or one of a number of qualitative disorders of vWF structure and function (vWD Type II).
 Application Notes for anti-VWF antibody    Suitable for use as a source of antibodies to rat vWF.
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NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    50950127
 NCBI GeneID    399544
 NCBI Accession #    NP_001002932.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002932.1 [Other Products]
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 UniProt Primary Accession #    Q28295 [Other Products]
 UniProt Secondary Accession #    Q28311; Q9TSI4 [Other Products]
 UniProt Related Accession #    Q28295 [Other Products]
 Molecular Weight    309533 Da [Similar Products]
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 NCBI Official Full Name    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    von Willebrand factor
 UniProt Protein Name    von Willebrand factor
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF [Similar Products]
 UniProt Entry Name    VWF_CANFA
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 UniProt Comments for VWF    Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

Subunit structure: Multimeric. Interacts with F8. Ref.2

Subcellular location: Secreted. Secreted › extracellular space › extracellular matrix. Note: Localized to storage granules. Ref.2

Tissue specificity: Plasma.

Domain: The propeptide is required for multimerization of vWF and for its targeting to storage granules.

Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds

By similarity.N- and O-glycosylated

Involvement in disease: Note=Defects in VWF are the cause of von Willebrand disease (VWD) in the Scottish Terrier. VWD is characterized by frequent bleeding. Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. Ref.4

Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 4 TIL (trypsin inhibitory-like) domains.Contains 3 VWFA domains.Contains 3 VWFC domains.Contains 4 VWFD domains.
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Product References and Citations for anti-VWF antibody

   1. Montgomery RR, Coller BS, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 134-168, J.B. Lippincott Co., Philadelphia PA, USA, 1994.
2. Sadler JE; von Willebrand Factor (Minireview); JBC 266:34, pp 22777- 22780, 1991.
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 Research Articles on VWF    1. the CD-31 and vonWillebrand factor (vWF) expressions and the cell morphological alterations ofarachnoid villus endothelium in different stages of animal hydrocephalus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VWF antibodyDiseases associated with anti-VWF antibody
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 von Willebrand Diseases Antibodies  >1739 publications with VWF and von Willebrand Diseases
 Cardiovascular Diseases Antibodies  >1608 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1170 publications with VWF and Thrombosis
 Inflammation Antibodies  >432 publications with VWF and Inflammation
 Purpura Antibodies  >397 publications with VWF and Purpura
 Thrombophilia Antibodies  >392 publications with VWF and Thrombophilia
 Neoplasms Antibodies  >374 publications with VWF and Neoplasms
 Coronary Disease Antibodies  >278 publications with VWF and Coronary Disease
 Kidney Diseases Antibodies  >274 publications with VWF and Kidney Diseases
 Arteriosclerosis Antibodies  >243 publications with VWF and Arteriosclerosis
Organs/Tissues associated with anti-VWF antibody
 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >660 publications with VWF and Artery
 Muscle Antibodies  >281 publications with VWF and Muscle
 Kidney Antibodies  >226 publications with VWF and Kidney
 Liver Antibodies  >206 publications with VWF and Liver
 Brain Antibodies  >187 publications with VWF and Brain
 Eye Antibodies  >45 publications with VWF and Eye
 Female Genital Antibodies  >36 publications with VWF and Female Genital
 Testis Antibodies  >3 publications with VWF and Testis
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