NP_005421.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 41 kDa Predicted: 41 kDa
NCBI Official Full Name
proto-oncogene Wnt-1
NCBI Official Synonym Full Names
Wnt family member 1
NCBI Protein Information
proto-oncogene Wnt-1
UniProt Protein Name
Proto-oncogene Wnt-1
UniProt Synonym Protein Names
Proto-oncogene Int-1 homolog
UniProt Synonym Gene Names
NCBI Summary for wnt1
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
UniProt Comments for wnt1
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).
Product References and Citations for anti-wnt1 antibody
Tang H, Peng F, Huang X, Xie X, Chen B, Shen J, Gao F, You J, Xie X, Chen J; Journal: Curr Cancer Drug Targets. Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-beta-catenin Signaling in Breast Cancer. Tong Lu, Huayou Luo, Jia Liu, Cheng Chen, Feng Wang, Zongwen Shen, Tonglei Liu, Yujian Zeng, Ting-Hua Wang, Kun-Hua Wang; Journal: Int J Clin Exp Pathol.
Research Articles on wnt1
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Products associated with anti-wnt1 antibody
Pathways associated with anti-wnt1 antibody
Diseases associated with anti-wnt1 antibody
Organs/Tissues associated with anti-wnt1 antibody
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