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anti-ZC3HC1 antibody :: Rabbit zinc finger, C3HC-type containing 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711057 anti-ZC3HC1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

zinc finger, C3HC-type containing 1 (ZC3HC1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human zinc finger, C3HC-type containing 1 polyclonal Antibody

 Product Synonym Names    zinc finger; C3HC-type containing 1; ZC3HC1; 1110054L24Rik; HSPC216; NIPA
 Product Gene Name   

anti-ZC3HC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ZC3HC1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48603 / sc-48605
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ZC3HC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ZC3HC1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ZC3HC1. It may not necessarily be applicable to this product.
 NCBI GI #    15079422
 NCBI GeneID    51530
 NCBI Accession #    AAH11551.1 [Other Products]
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 UniProt Secondary Accession #    Q75MF3; Q75MF4; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0; A6NH66 [Other Products]
 UniProt Related Accession #    Q86WB0 [Other Products]
 Molecular Weight    47,771 Da [Similar Products]
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 NCBI Official Full Name    Zinc finger, C3HC-type containing 1
 NCBI Official Synonym Full Names    zinc finger, C3HC-type containing 1
 NCBI Official Symbol    ZC3HC1 [Similar Products]
 NCBI Official Synonym Symbols   
NIPA; HSPC216
[Similar Products]
 NCBI Protein Information    nuclear-interacting partner of ALK; hematopoietic stem/progenitor cell protein 216; nuclear interacting partner of anaplastic lymphoma kinase (ALK)
 UniProt Protein Name    Nuclear-interacting partner of ALK
 UniProt Synonym Protein Names   
Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1
 Protein Family    NIPA-like protein
 UniProt Gene Name    ZC3HC1 [Similar Products]
 UniProt Synonym Gene Names    NIPA; hNIPA [Similar Products]
 UniProt Entry Name    NIPA_HUMAN
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 NCBI Summary for ZC3HC1    This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
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 UniProt Comments for ZC3HC1    NIPA: a nuclear protein that interacts with anaplastic lymphoma kinase (ALK). An essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1. Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting cyclin B1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of cyclin B1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Three splice-variant isoforms have been described.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 7q32.2

Cellular Component: nuclear membrane; nucleus

Molecular Function: protein binding; zinc ion binding; protein kinase binding

Biological Process: mitosis; cell division; protein ubiquitination
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 Research Articles on ZC3HC1    1. Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ZC3HC1 antibodyOrgans/Tissues associated with anti-ZC3HC1 antibody
 Disease Name  Pubmed Publications
 Coronary Artery Disease Antibodies  >2 publications with ZC3HC1 and Coronary Artery Disease
 Heart Diseases Antibodies  >1 publications with ZC3HC1 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with ZC3HC1 and Liver Diseases
 Nervous System Malformations Antibodies  >1 publications with ZC3HC1 and Nervous System Malformations
 Inflammation Antibodies  >1 publications with ZC3HC1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with ZC3HC1 and Heart
 Liver Antibodies  >1 publications with ZC3HC1 and Liver
 Bone Antibodies  >1 publications with ZC3HC1 and Bone
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