NP_004295.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,442 Da
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma receptor tyrosine kinase
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Entry Name
ALK_HUMAN
NCBI Summary for ALK
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK
ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors
Protein type: Alk family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: integral to plasma membrane; protein complex
Molecular Function: identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cell proliferation; neuron development; phosphorylation; protein amino acid autophosphorylation; regulation of apoptosis; signal transduction
Disease: Neuroblastoma, Susceptibility To, 3
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Products associated with anti-ALK antibody
Pathways associated with anti-ALK antibody
Diseases associated with anti-ALK antibody
Disease Name |
Pubmed Publications |
Respiratory Tract Diseases Antibodies |
>1590 publications with ALK and Respiratory Tract Diseases |
Lung Diseases Antibodies |
>1505 publications with ALK and Lung Diseases |
Lung Neoplasms Antibodies |
>1503 publications with ALK and Lung Neoplasms |
Lymphoma, Large-Cell, Anaplastic Antibodies |
>1277 publications with ALK and Lymphoma, Large-Cell, Anaplastic |
Carcinoma, Non-Small-Cell Lung Antibodies |
>993 publications with ALK and Carcinoma, Non-Small-Cell Lung |
Chromosome Aberrations Antibodies |
>393 publications with ALK and Chromosome Aberrations |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>364 publications with ALK and Lymphoma, Large B-Cell, Diffuse |
Neuroblastoma Antibodies |
>244 publications with ALK and Neuroblastoma |
Adenocarcinoma of lung Antibodies |
>197 publications with ALK and Adenocarcinoma of lung |
Brain Neoplasms Antibodies |
>145 publications with ALK and Brain Neoplasms |
Organs/Tissues associated with anti-ALK antibody
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