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anti-Bim antibody :: Rabbit Bim Polycolonal Antibody

Scan QR to view Datasheet Catalog #    MBS9416667
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bim, Polycolonal Antibody

★Popular Item★
 Also Known As   

Bim (Phospho-Thr56/116) Antibody

 Product Synonym Names    BCL2L11; BIM-alpha6; BIM-beta7; Bcl-2-like protein 11; BIM-beta6; BimL; BimS; Bcl-2 interacting protein Bim; BimEL; BAM; Bcl2-L-11; BIM; BOD
 Product Gene Name   

anti-Bim antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF032457 mRNA
 3D Structure    ModBase 3D Structure for O43521
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 Clonality    Polycolonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Bim (Phospho-Thr56/116) Antibody detects endogenous levels of Bim only when phosphorylated at Thr56/116
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi non-phosphopeptide
 Immunogen    A synthesized peptide derived from human Bim (Phospho-Thr56/116)
  Immunogen Type    Peptide
 Target Species    human
 Modification    Phospho-Thr56/116
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-Bim antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Bim antibody

   Rabbit Polyclonal Antibody
 Product Categories/Family for anti-Bim antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-Bim antibody   

Western Blot (WB)

 Application Notes for anti-Bim antibody    Western Blot: 1:1000
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 Western Blot (WB) of anti-Bim antibody    Western blot analysis Bim (Phospho-Thr56/116) using EGF treated 293 whole cell lysates
anti-Bim antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Bim. It may not necessarily be applicable to this product.
 NCBI GI #    323362959
 NCBI GeneID    10018
 NCBI Accession #    NP_001191035.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204106.1 [Other Products]
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 UniProt Primary Accession #    O43521 [Other Products]
 UniProt Secondary Accession #    O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; A8K2W2 [Other Products]
 UniProt Related Accession #    O43521 [Other Products]
 Molecular Weight    25kd, 22kd
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 NCBI Official Full Name    bcl-2-like protein 11 isoform 11
 NCBI Official Synonym Full Names    BCL2 like 11
 NCBI Official Symbol    BCL2L11 [Similar Products]
 NCBI Official Synonym Symbols   
BAM; BIM; BOD
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 11
 UniProt Protein Name    Bcl-2-like protein 11
 UniProt Synonym Protein Names   
Bcl2-interacting mediator of cell death
 UniProt Gene Name    BCL2L11 [Similar Products]
 UniProt Synonym Gene Names    BIM; Bcl2-L-11 [Similar Products]
 UniProt Entry Name    B2L11_HUMAN
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 NCBI Summary for Bim    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
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 UniProt Comments for Bim    BIM: a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion

Molecular Function: protein binding

Biological Process: apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; meiosis I; positive regulation of apoptosis; positive regulation of protein homooligomerization; protein insertion into mitochondrial membrane during induction of apoptosis
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 Research Articles on Bim    1. FOXO4 has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim in the mitochondria-dependent pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Bim antibodyPathways associated with anti-Bim antibody
 Reference Product  PubMed Publications
 BAX antibody  >362 publications with Bim and BAX
 BCL2L1 antibody  >212 publications with Bim and BCL2L1
 JUN antibody  >210 publications with Bim and JUN
 BCL2 antibody  >115 publications with Bim and BCL2
 MCL1 antibody  >93 publications with Bim and MCL1
 FOXO3 antibody  >83 publications with Bim and FOXO3
 MAPK8 antibody  >15 publications with Bim and MAPK8
 BCL2L2 antibody  >15 publications with Bim and BCL2L2
 DYNLL1 antibody  >5 publications with Bim and DYNLL1
 MAPK9 antibody  >1 publications with Bim and MAPK9
 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of BIM And Translocation To Mitochondria Pathway antibodies  Activation Of BIM And Translocation To Mitochondria Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
Diseases associated with anti-Bim antibodyOrgans/Tissues associated with anti-Bim antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >89 publications with Bim and Nervous System Diseases
 Breast Neoplasms Antibodies  >78 publications with Bim and Breast Neoplasms
 Necrosis Antibodies  >77 publications with Bim and Necrosis
 Lung Neoplasms Antibodies  >76 publications with Bim and Lung Neoplasms
 Brain Diseases Antibodies  >66 publications with Bim and Brain Diseases
 Disease Models, Animal Antibodies  >65 publications with Bim and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >63 publications with Bim and Cardiovascular Diseases
 Liver Diseases Antibodies  >53 publications with Bim and Liver Diseases
 Inflammation Antibodies  >48 publications with Bim and Inflammation
 Multiple Myeloma Antibodies  >36 publications with Bim and Multiple Myeloma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >378 publications with Bim and Blood
 Brain Antibodies  >113 publications with Bim and Brain
 Lung Antibodies  >110 publications with Bim and Lung
 Bone Antibodies  >89 publications with Bim and Bone
 Liver Antibodies  >86 publications with Bim and Liver
 Nerve Antibodies  >51 publications with Bim and Nerve
 Thymus Antibodies  >50 publications with Bim and Thymus
 Kidney Antibodies  >39 publications with Bim and Kidney
 Muscle Antibodies  >28 publications with Bim and Muscle
 Heart Antibodies  >28 publications with Bim and Heart
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