NP_001076580.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,380 Da
NCBI Official Full Name
progonadoliberin-1 isoform 2 preproprotein
NCBI Official Synonym Full Names
gonadotropin releasing hormone 1
NCBI Protein Information
progonadoliberin-1
UniProt Protein Name
Progonadoliberin-1
UniProt Synonym Protein Names
Progonadoliberin I
UniProt Synonym Gene Names
UniProt Entry Name
GON1_HUMAN
NCBI Summary for GnRH I
This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
UniProt Comments for GnRH I
GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.
Protein type: Cell cycle regulation; Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p21-p11.2
Cellular Component: extracellular region
Molecular Function: hormone activity
Biological Process: cell-cell signaling; multicellular organismal development; negative regulation of cell proliferation; signal transduction
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Research Articles on GnRH I
Precautions
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Disclaimer
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Products associated with anti-GnRH I antibody
Pathways associated with anti-GnRH I antibody
Diseases associated with anti-GnRH I antibody
Organs/Tissues associated with anti-GnRH I antibody
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