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anti-RIPK1 antibody :: Rabbit anti-Human RIPK1 Polycolonal Antibody

Scan QR to view Datasheet Catalog #    MBS9418272
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIPK1, Polycolonal Antibody

 Also Known As   

RIPK1 Antibody

 Product Synonym Names    Cell death protein RIP antibody
 Product Gene Name   

anti-RIPK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U50062 mRNA
 3D Structure    ModBase 3D Structure for Q13546
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 Clonality    Polycolonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    RIPK1antibody detects endogenous levels of total RIPK1
 Form/Format    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0mg/mL (lot specific)
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 Immunogen    A synthesized peptide derived from human RIPK1
 Immunogen Type    Peptide
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-RIPK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RIPK1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-RIPK1 antibody   

Western Blot (WB)

 Application Notes for anti-RIPK1 antibody    Western Blot: 1:500-1:2000
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 Western Blot (WB) of anti-RIPK1 antibody    Western blot analysis of RIPK1 expression in Rat kidney tissue lysate,The lane on the left is treated with the antigen-specific peptide.
anti-RIPK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RIPK1. It may not necessarily be applicable to this product.
 NCBI GI #    951231042
 NCBI GeneID    8737
 NCBI Accession #    NP_001303990.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001317061.1 [Other Products]
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 UniProt Primary Accession #    Q13546 [Other Products]
 UniProt Secondary Accession #    Q13180; Q59H33; A0AV89; B2RAG1; B4E3F9 [Other Products]
 UniProt Related Accession #    Q13546 [Other Products]
 Molecular Weight    70,733 Da
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 1 isoform 2
 NCBI Official Synonym Full Names    receptor interacting serine/threonine kinase 1
 NCBI Official Symbol    RIPK1 [Similar Products]
 NCBI Official Synonym Symbols   
RIP; RIP1; RIP-1
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 1
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 1
 UniProt Synonym Protein Names   
Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK1 [Similar Products]
 UniProt Synonym Gene Names    RIP; RIP1; RIP-1 [Similar Products]
 UniProt Entry Name    RIPK1_HUMAN
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 UniProt Comments for RIPK1    RIPK1: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex. Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Inhibited by necrostatin-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: cytoplasm; cytosol; mitochondrion; receptor complex

Molecular Function: death receptor binding; identical protein binding; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity; ubiquitin protein ligase binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; apoptosis; caspase activation; cellular protein catabolic process; I-kappaB kinase/NF-kappaB cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization; tumor necrosis factor-mediated signaling pathway
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 Research Articles on RIPK1    1. Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK1 antibodyPathways associated with anti-RIPK1 antibody
 Reference Product  PubMed Publications
 RIPK3 antibody  >199 publications with RIPK1 and RIPK3
 CASP8 antibody  >172 publications with RIPK1 and CASP8
 FADD antibody  >125 publications with RIPK1 and FADD
 TRADD antibody  >61 publications with RIPK1 and TRADD
 TRAF2 antibody  >49 publications with RIPK1 and TRAF2
 TRAF1 antibody  >34 publications with RIPK1 and TRAF1
 TNFRSF1A antibody  >16 publications with RIPK1 and TNFRSF1A
 BIRC2 antibody  >6 publications with RIPK1 and BIRC2
 IKBKG antibody  >6 publications with RIPK1 and IKBKG
 Products by Pathway  Pathway Diagram
 ATM Signaling Pathway antibodies  ATM Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 CASP8 Activity Is Inhibited Pathway antibodies  CASP8 Activity Is Inhibited Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalling Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalling Pathway Diagram
Diseases associated with anti-RIPK1 antibodyOrgans/Tissues associated with anti-RIPK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >369 publications with RIPK1 and Necrosis
 Inflammation Antibodies  >140 publications with RIPK1 and Inflammation
 Cardiovascular Diseases Antibodies  >24 publications with RIPK1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >23 publications with RIPK1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >19 publications with RIPK1 and Nervous System Diseases
 Liver Diseases Antibodies  >14 publications with RIPK1 and Liver Diseases
 Heart Diseases Antibodies  >11 publications with RIPK1 and Heart Diseases
 Kidney Diseases Antibodies  >9 publications with RIPK1 and Kidney Diseases
 Lung Diseases Antibodies  >9 publications with RIPK1 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >7 publications with RIPK1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with RIPK1 and Brain
 Liver Antibodies  >25 publications with RIPK1 and Liver
 Lung Antibodies  >24 publications with RIPK1 and Lung
 Kidney Antibodies  >21 publications with RIPK1 and Kidney
 Bone Antibodies  >16 publications with RIPK1 and Bone
 Embryonic Tissue Antibodies  >14 publications with RIPK1 and Embryonic Tissue
 Bone Marrow Antibodies  >13 publications with RIPK1 and Bone Marrow
 Skin Antibodies  >11 publications with RIPK1 and Skin
 Intestine Antibodies  >10 publications with RIPK1 and Intestine
 Muscle Antibodies  >9 publications with RIPK1 and Muscle
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