NP_001307572.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
Molecular Weight
84,902 Da
NCBI Official Full Name
serine/threonine-protein kinase SIK1
NCBI Protein Information
serine/threonine-protein kinase SIK1
UniProt Protein Name
Serine/threonine-protein kinase SIK1
UniProt Synonym Protein Names
Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK
UniProt Synonym Gene Names
UniProt Comments for QIK/QSK
SIK: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. Interacts with ATP1A1. Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily; Tumor suppressor
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; cAMP response element binding protein binding; magnesium ion binding; protein binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process: cardiac muscle cell differentiation; cellular response to hormone stimulus; entrainment of circadian clock by photoperiod; inhibition of CREB transcription factor; negative regulation of gluconeogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell differentiation; regulation of mitotic cell cycle; regulation of sodium ion transport
Disease: Epileptic Encephalopathy, Early Infantile, 30
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-QIK/QSK antibody
|