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anti-RFA2 antibody :: Rabbit anti-Human, mouse RFA2 (Ab-21) Antibody

Scan QR to view Datasheet Catalog #    MBS003450 anti-RFA2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RFA2 (Ab-21), Antibody

 Also Known As   

Rabbit RFA2 (Ab-21) Antibody

 Product Gene Name   

anti-RFA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (28218049..28241236, complement). Location: 1p35
 OMIM    179836
 3D Structure    ModBase 3D Structure for P15927
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-RFA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RFA2 antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RFA2. It may not necessarily be applicable to this product.
 NCBI GI #    4506585
 NCBI GeneID    6118
 NCBI Accession #    NP_002937.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002946.3 [Other Products]
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 UniProt Primary Accession #    P15927 [Other Products]
 UniProt Secondary Accession #    Q52II0; Q5TEI9; Q5TEJ5 [Other Products]
 UniProt Related Accession #    P15927 [Other Products]
 Molecular Weight    29,247 Da
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 NCBI Official Full Name    replication protein A 32 kDa subunit
 NCBI Official Synonym Full Names    replication protein A2, 32kDa
 NCBI Official Symbol    RPA2 [Similar Products]
 NCBI Official Synonym Symbols   
REPA2; RPA32
[Similar Products]
 NCBI Protein Information    replication protein A 32 kDa subunit; RP-A p32; RP-A p34; RF-A protein 2; replication factor A protein 2; replication protein A 34 kDa subunit
 UniProt Protein Name    Replication protein A 32 kDa subunit
 UniProt Synonym Protein Names   
Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit
 Protein Family    Replication factor A protein
 UniProt Gene Name    RPA2 [Similar Products]
 UniProt Synonym Gene Names    REPA2; RPA32; RPA34; RP-A p32; RF-A protein 2; RP-A p34 [Similar Products]
 UniProt Entry Name    RFA2_HUMAN
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 UniProt Comments for RFA2    RFA2: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage. Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. Directly interacts with PPP4R2, but not with SMEK2; this interaction is DNA damage-dependent and leads RPA2 dephosphorylation by PPP4C recruitment. Interacts with RAD51, preferentially when hyperphosphorylated. Directly interacts with RFWD3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; DNA replication factor A complex; nucleus

Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; damaged DNA binding; protein N-terminus binding; protein phosphatase binding; single-stranded DNA binding

Biological Process: G1 DNA damage checkpoint; mismatch repair; DNA strand elongation during DNA replication; DNA repair; double-strand break repair via homologous recombination; telomere maintenance via semi-conservative replication; DNA recombinase assembly; nucleotide-excision repair; base-excision repair; transcription-coupled nucleotide-excision repair; double-strand break repair; telomere maintenance via recombination; nucleotide-excision repair, DNA damage removal; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; DNA replication; telomere maintenance; G1/S transition of mitotic cell cycle
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 Research Articles on RFA2    1. this study has explored the role of RPA32 phosphorylation at CDK and ATR sites and propose that phosphorylation of the RPA32 subunit is dispensable for checkpoint activation induced by replication stress with aphidicolin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RFA2 antibodyPathways associated with anti-RFA2 antibody
 Reference Product  PubMed Publications
 RPA1 antibody  >50 publications with RFA2 and RPA1
 RPA3 antibody  >34 publications with RFA2 and RPA3
 PRKDC antibody  >7 publications with RFA2 and PRKDC
 XPA antibody  >4 publications with RFA2 and XPA
 MEN1 antibody  >4 publications with RFA2 and MEN1
 MCM2 antibody  >3 publications with RFA2 and MCM2
 UNG antibody  >2 publications with RFA2 and UNG
 MCM5 antibody  >2 publications with RFA2 and MCM5
 RAD52 antibody  >1 publications with RFA2 and RAD52
 CCNO antibody  >1 publications with RFA2 and CCNO
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The RAD51-ssDNA Nucleoprotein Complex Pathway antibodies  Assembly Of The RAD51-ssDNA Nucleoprotein Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-RFA2 antibodyOrgans/Tissues associated with anti-RFA2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with RFA2 and Neoplasms
 Drug Toxicity Antibodies  >3 publications with RFA2 and Drug Toxicity
 Adenocarcinoma Antibodies  >3 publications with RFA2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >3 publications with RFA2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with RFA2 and Kidney Diseases
 Nervous System Diseases Antibodies  >2 publications with RFA2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with RFA2 and Carcinoma, Hepatocellular
 Urinary Bladder Neoplasms Antibodies  >1 publications with RFA2 and Urinary Bladder Neoplasms
 Disease Models, Animal Antibodies  >1 publications with RFA2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with RFA2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Ganglia Antibodies  >6 publications with RFA2 and Ganglia
 Brain Antibodies  >4 publications with RFA2 and Brain
 Blood Antibodies  >3 publications with RFA2 and Blood
 Kidney Antibodies  >3 publications with RFA2 and Kidney
 Bone Antibodies  >2 publications with RFA2 and Bone
 Lymph Node Antibodies  >2 publications with RFA2 and Lymph Node
 Bone Marrow Antibodies  >2 publications with RFA2 and Bone Marrow
 Lymph Antibodies  >2 publications with RFA2 and Lymph
 Skin Antibodies  >1 publications with RFA2 and Skin
 Mouth Antibodies  >1 publications with RFA2 and Mouth
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