NP_002913.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,858 Da
NCBI Official Full Name
regulator of G-protein signaling 1
NCBI Official Synonym Full Names
regulator of G-protein signaling 1
NCBI Protein Information
regulator of G-protein signaling 1; early response protein 1R20; B-cell activation protein BL34; regulator of G-protein signalling 1; immediate-early response 1, B-cell specific
UniProt Protein Name
Regulator of G-protein signaling 1
UniProt Synonym Protein Names
B-cell activation protein BL34; Early response protein 1R20
UniProt Synonym Gene Names
UniProt Entry Name
RGS1_HUMAN
NCBI Summary for RGS1
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
UniProt Comments for RGS1
RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytoplasm; plasma membrane
Molecular Function: calmodulin binding; GTPase activator activity
Biological Process: immune response; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; positive regulation of GTPase activity
Research Articles on RGS1
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Products associated with anti-RGS1 antibody
Pathways associated with anti-RGS1 antibody
Diseases associated with anti-RGS1 antibody
Organs/Tissues associated with anti-RGS1 antibody
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