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anti-RIPK2 antibody :: anti-Human, Mouse RIPK2 Antibody

Scan QR to view Datasheet Catalog #    MBS854491
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIPK2, Antibody

 Also Known As   

RIPK2 (Phospho-Ser176) Antibody

 Product Synonym Names    CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta converting enzyme associated kinase; CARDIAK; EC; kinase RIPK2; Receptor-interacting protein 2; Receptor-interacting serine/threonine protein kinase 2; RICK; RIP-2; RIP-like interacting CLARP kinase; RIP2; RIPK2
 Product Gene Name   

anti-RIPK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603455
 3D Structure    ModBase 3D Structure for O43353
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 Species Reactivity    Human, Mouse
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 Specificity    RIPK2 (Phospho-Ser176) antibody detects endogenous levels of RIPK2 only when phosphorylated at serine 176.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human RIPK2 around the phosphorylation site of serine 176 (S-L-SP-Q-S).
 All Sites    Human: Ser176
Mouse: Ser176
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-RIPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RIPK2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-RIPK2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-RIPK2 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:40000
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 Testing Data of anti-RIPK2 antibody    P-peptide-+
anti-RIPK2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-RIPK2 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Phospho-Ser176) antibody. Western blot analysis of extracts from 293 cells, treated with UV (15mins), using RIPK2 (Phospho-Ser176) antibody.
anti-RIPK2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RIPK2. It may not necessarily be applicable to this product.
 NCBI GI #    4506537
 NCBI GeneID    8767
 NCBI Accession #    NP_003812.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003821.5 [Other Products]
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 UniProt Primary Accession #    O43353 [Other Products]
 UniProt Secondary Accession #    Q6UWF0; B7Z748 [Other Products]
 UniProt Related Accession #    O43353 [Other Products]
 Molecular Weight    45,582 Da
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 2
 NCBI Official Synonym Full Names    receptor interacting serine/threonine kinase 2
 NCBI Official Symbol    RIPK2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 2
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 2
 UniProt Synonym Protein Names   
CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK2 [Similar Products]
 UniProt Synonym Gene Names    CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2 [Similar Products]
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 NCBI Summary for RIPK2    This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RIPK2    Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
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Product References and Citations for anti-RIPK2 antibody

   Inohara N., J. Biol. Chem. 273:12296-12300(1998). McCarthy J.V., J. Biol. Chem. 273:16968-16975(1998). Thome M., Curr. Biol. 8:885-888(1998).
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 Research Articles on RIPK2    1. Together, these data show that RIP2 promotes survival of breast cancer cells through NF-kappaB activation and that targeting RIP2 may be therapeutically beneficial for treatment of TNBC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK2 antibodyPathways associated with anti-RIPK2 antibody
 Reference Product  PubMed Publications
 NOD2 antibody  >86 publications with RIPK2 and NOD2
 NOD1 antibody  >55 publications with RIPK2 and NOD1
 CASP1 antibody  >30 publications with RIPK2 and CASP1
 TLR4 antibody  >17 publications with RIPK2 and TLR4
 TRAF6 antibody  >14 publications with RIPK2 and TRAF6
 TLR2 antibody  >14 publications with RIPK2 and TLR2
 CASP8 antibody  >6 publications with RIPK2 and CASP8
 BIRC3 antibody  >5 publications with RIPK2 and BIRC3
 BCL10 antibody  >5 publications with RIPK2 and BCL10
 TRAF2 antibody  >5 publications with RIPK2 and TRAF2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
Diseases associated with anti-RIPK2 antibodyOrgans/Tissues associated with anti-RIPK2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >54 publications with RIPK2 and Inflammation
 Necrosis Antibodies  >50 publications with RIPK2 and Necrosis
 Neoplasms Antibodies  >16 publications with RIPK2 and Neoplasms
 Nervous System Diseases Antibodies  >10 publications with RIPK2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with RIPK2 and Disease Models, Animal
 Liver Diseases Antibodies  >5 publications with RIPK2 and Liver Diseases
 Heart Diseases Antibodies  >4 publications with RIPK2 and Heart Diseases
 Colitis, Ulcerative Antibodies  >4 publications with RIPK2 and Colitis, Ulcerative
 Hepatitis Antibodies  >3 publications with RIPK2 and Hepatitis
 Drug Toxicity Antibodies  >2 publications with RIPK2 and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with RIPK2 and Blood
 Intestine Antibodies  >15 publications with RIPK2 and Intestine
 Bone Antibodies  >12 publications with RIPK2 and Bone
 Bone Marrow Antibodies  >11 publications with RIPK2 and Bone Marrow
 Lung Antibodies  >10 publications with RIPK2 and Lung
 Liver Antibodies  >9 publications with RIPK2 and Liver
 Brain Antibodies  >9 publications with RIPK2 and Brain
 Heart Antibodies  >8 publications with RIPK2 and Heart
 Kidney Antibodies  >8 publications with RIPK2 and Kidney
 Spleen Antibodies  >7 publications with RIPK2 and Spleen
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