NP_001135751.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,005 Da
NCBI Official Full Name
ribonuclease H2 subunit B isoform 2
NCBI Official Synonym Full Names
ribonuclease H2 subunit B
NCBI Official Synonym Symbols
NCBI Protein Information
ribonuclease H2 subunit B
UniProt Protein Name
Ribonuclease H2 subunit B
UniProt Synonym Protein Names
Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B
UniProt Synonym Gene Names
NCBI Summary for RNASEH2B
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
UniProt Comments for RNASEH2B
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Research Articles on RNASEH2B
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Products associated with anti-RNASEH2B antibody
Pathways associated with anti-RNASEH2B antibody
Diseases associated with anti-RNASEH2B antibody
Organs/Tissues associated with anti-RNASEH2B antibody
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