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anti-ROBO2 antibody :: Rabbit ROBO2 Antibody

Scan QR to view Datasheet Catalog #    MBS004507 anti-ROBO2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ROBO2, Antibody

 Also Known As   

Rabbit ROBO2 Antibody

 Product Gene Name   

anti-ROBO2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (75955845..77699115). Location: 3p12.3
 OMIM    602431
 3D Structure    ModBase 3D Structure for Q9HCK4
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ROBO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ROBO2 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ROBO2. It may not necessarily be applicable to this product.
 NCBI GI #    193083163
 NCBI GeneID    6092
 NCBI Accession #    NP_001122401.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001128929.2 [Other Products]
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 UniProt Primary Accession #    Q9HCK4 [Other Products]
 UniProt Secondary Accession #    O43608; Q19AB4; Q19AB5 [Other Products]
 UniProt Related Accession #    Q9HCK4 [Other Products]
 Molecular Weight    151,200 Da
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 NCBI Official Full Name    roundabout homolog 2 isoform ROBO2a
 NCBI Official Synonym Full Names    roundabout, axon guidance receptor, homolog 2 (Drosophila)
 NCBI Official Symbol    ROBO2 [Similar Products]
 NCBI Official Synonym Symbols   
SAX3
[Similar Products]
 NCBI Protein Information    roundabout homolog 2
 UniProt Protein Name    Roundabout homolog 2
 Protein Family    Roundabout
 UniProt Gene Name    ROBO2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1568 [Similar Products]
 UniProt Entry Name    ROBO2_HUMAN
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 NCBI Summary for ROBO2    This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ROBO2    ROBO2: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT- ROBO signaling in vitro. Belongs to the immunoglobulin superfamily. ROBO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 3p12.3

Cellular Component: cell surface; integral to membrane; axolemma

Molecular Function: identical protein binding; protein binding; axon guidance receptor activity

Biological Process: axon guidance; central nervous system development; olfactory bulb interneuron development; negative regulation of synaptogenesis; axon midline choice point recognition; cellular response to hormone stimulus; negative regulation of negative chemotaxis; ureteric bud development; positive regulation of axonogenesis; brain development; homophilic cell adhesion; metanephros development; retinal ganglion cell axon guidance

Disease: Vesicoureteral Reflux 2
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 Research Articles on ROBO2    1. data suggests the importance of abrogation of SLIT2-ROBO1 and SLIT2-ROBO2 interactions in the initiation and progression of CACX and also for early diagnosis and prognosis of the disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ROBO2 antibodyPathways associated with anti-ROBO2 antibody
 Reference Product  PubMed Publications
 ROBO1 antibody  >72 publications with ROBO2 and ROBO1
 SLIT2 antibody  >62 publications with ROBO2 and SLIT2
 SLIT3 antibody  >28 publications with ROBO2 and SLIT3
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway antibodies  Regulation Of Commissural Axon Pathfinding By Slit And Robo Pathway Diagram
 Signaling By Robo Receptor Pathway antibodies  Signaling By Robo Receptor Pathway Diagram
Diseases associated with anti-ROBO2 antibodyOrgans/Tissues associated with anti-ROBO2 antibody
 Disease Name  Pubmed Publications
 Vesico-Ureteral Reflux Antibodies  >9 publications with ROBO2 and Vesico-Ureteral Reflux
 Nervous System Diseases Antibodies  >6 publications with ROBO2 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >5 publications with ROBO2 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >2 publications with ROBO2 and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >2 publications with ROBO2 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with ROBO2 and Liver Diseases
 Schizophrenia Antibodies  >2 publications with ROBO2 and Schizophrenia
 Nerve Degeneration Antibodies  >1 publications with ROBO2 and Nerve Degeneration
 Abnormalities, Drug-Induced Antibodies  >1 publications with ROBO2 and Abnormalities, Drug-Induced
 Hypertension Antibodies  >1 publications with ROBO2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >72 publications with ROBO2 and Brain
 Embryonic Tissue Antibodies  >53 publications with ROBO2 and Embryonic Tissue
 Eye Antibodies  >23 publications with ROBO2 and Eye
 Muscle Antibodies  >9 publications with ROBO2 and Muscle
 Vascular Antibodies  >6 publications with ROBO2 and Vascular
 Heart Antibodies  >5 publications with ROBO2 and Heart
 Ovary Antibodies  >3 publications with ROBO2 and Ovary
 Connective Tissue Antibodies  >2 publications with ROBO2 and Connective Tissue
 Lung Antibodies  >2 publications with ROBO2 and Lung
 Uterus Antibodies  >1 publications with ROBO2 and Uterus
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