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anti-RPA2 antibody :: Rabbit RPA2 Antibody

Scan QR to view Datasheet Catalog #    MBS003721 anti-RPA2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RPA2, Antibody

 Also Known As   

Rabbit RPA2 Antibody

 Product Gene Name   

anti-RPA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (113299492..113334727). Location: 2q13
 OMIM    602000
 3D Structure    ModBase 3D Structure for Q9H9Y6
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-RPA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RPA2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RPA2. It may not necessarily be applicable to this product.
 NCBI GI #    212286172
 NCBI GeneID    84172
 NCBI Accession #    NP_001131076.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001137604.1 [Other Products]
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 UniProt Primary Accession #    Q9H9Y6 [Other Products]
 UniProt Secondary Accession #    Q585T5; Q6ZRR2; Q9H9D3 [Other Products]
 UniProt Related Accession #    Q9H9Y6 [Other Products]
 Molecular Weight    128,229 Da
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 NCBI Official Full Name    DNA-directed RNA polymerase I subunit RPA2 isoform 2
 NCBI Official Synonym Full Names    polymerase (RNA) I polypeptide B, 128kDa
 NCBI Official Symbol    POLR1B [Similar Products]
 NCBI Official Synonym Symbols   
RPA2; RPA135; Rpo1-2
[Similar Products]
 NCBI Protein Information    DNA-directed RNA polymerase I subunit RPA2; RNA polymerase I subunit 2; DNA-directed RNA polymerase I 135kDa polypeptide; DNA-directed RNA polymerase I 135 kDa polypeptide
 UniProt Protein Name    DNA-directed RNA polymerase I subunit RPA2
 UniProt Synonym Protein Names   
DNA-directed RNA polymerase I 135 kDa polypeptide
 Protein Family    Replication protein
 UniProt Gene Name    POLR1B [Similar Products]
 UniProt Synonym Gene Names    RNA polymerase I subunit 2; RPA135 [Similar Products]
 UniProt Entry Name    RPA2_HUMAN
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 NCBI Summary for RPA2    Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RPA2    POLR1B: a subunit of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase that synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef. Two alternatively spliced human isoforms have been described.

Protein type: Transcription initiation complex; Nucleotide Metabolism - pyrimidine; EC 2.7.7.6; Nucleolus; Nucleotide Metabolism - purine; Transferase

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: nucleoplasm; cytoplasm; nucleolus; DNA-directed RNA polymerase I complex

Molecular Function: protein binding; DNA binding; ribonucleoside binding; metal ion binding

Biological Process: negative regulation of gene expression, epigenetic; nucleologenesis; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; regulation of gene expression, epigenetic; embryo implantation; rRNA transcription
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 Research Articles on RPA2    1. The average FIX expression level of the rDNA recombinants was additionally enhanced to that from a strong Pol II promoter as a result of elimination of position effects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPA2 antibodyPathways associated with anti-RPA2 antibody
 Reference Product  PubMed Publications
 RRN3 antibody  >1 publications with RPA2 and RRN3
 Products by Pathway  Pathway Diagram
 Eukaryotic Transcription Initiation Pathway antibodies  Eukaryotic Transcription Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 RNA Polymerase I Chain Elongation Pathway antibodies  RNA Polymerase I Chain Elongation Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Promoter Escape Pathway antibodies  RNA Polymerase I Promoter Escape Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
Diseases associated with anti-RPA2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with RPA2 and Neoplasms
 Drug Toxicity Antibodies  >1 publications with RPA2 and Drug Toxicity
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