NP_001137326.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
rabphilin-3A isoform 1
NCBI Official Synonym Full Names
rabphilin 3A homolog (mouse)
NCBI Protein Information
rabphilin-3A; exophilin-1
UniProt Protein Name
Rabphilin-3A
UniProt Synonym Protein Names
Exophilin-1
UniProt Synonym Gene Names
UniProt Entry Name
RP3A_HUMAN
NCBI Summary for RPH3A
Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).[supplied by OMIM, Jul 2008]
UniProt Comments for RPH3A
rabphilin 3A: Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component: Golgi apparatus; synaptic vesicle; neuron projection; protein complex; extrinsic to membrane; synaptic vesicle membrane; synapse; cytosol; cell junction; secretory granule
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; selenium binding; protein binding; zinc ion binding; calcium-dependent phospholipid binding; transporter activity; protein complex binding; calcium ion binding; phosphate binding; Rab GTPase binding
Biological Process: intracellular protein transport
Research Articles on RPH3A
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Pathways associated with anti-RPH3A antibody
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