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anti-RET antibody :: Ret Antibody

Scan QR to view Datasheet Catalog #    MBS8511304
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ret, Antibody

★Popular Item★
 Also Known As   

Phospho-Ret (Tyr1062) Antibody

 Product Synonym Names    C-ret; EC 2.7.10.1; Proto-oncogene ret precursor; kinase Ret
 Product Gene Name   

anti-RET antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AK291807 mRNA
 3D Structure    ModBase 3D Structure for P07949
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-Ret (Tyr1062) Antibody detects endogenous levels of Ret only when phosphorylated at Tyrosine 1062
 Purity/Purification    Immunogen Affinity Purified
 Form/Format    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    A synthesized peptide derived from human Ret around the phosphorylation site of Tyrosine 1062
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 Preparation and Storage    Store at -20C/1 year.
Store at -20C. Stable for 12 months from date of receipt).
 Other Notes    Small volumes of anti-RET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RET antibody

   This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.
 Applications Tested/Suitable for anti-RET antibody   

Western Blot (WB)

 Application Notes for anti-RET antibody    WB: 1: 500-1: 2000
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 Western Blot (WB) of anti-RET antibody    Western blot analysis of Ret phosphorylation expression in K562 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
anti-RET antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RET. It may not necessarily be applicable to this product.
 NCBI GI #    10862701
 NCBI GeneID    5979
 NCBI Accession #    NP_065681.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020630.4 [Other Products]
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 UniProt Primary Accession #    P07949 [Other Products]
 UniProt Secondary Accession #    Q15250; Q9BTB0; Q9H4A2; A8K6Z2 [Other Products]
 UniProt Related Accession #    P07949 [Other Products]
 Molecular Weight    175kDa [Similar Products]
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 NCBI Official Full Name    proto-oncogene tyrosine-protein kinase receptor Ret isoform c
 NCBI Official Synonym Full Names    ret proto-oncogene
 NCBI Official Symbol    RET [Similar Products]
 NCBI Official Synonym Symbols   
PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase receptor Ret
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase receptor Ret
 UniProt Synonym Protein Names   
Cadherin family member 12; Proto-oncogene c-Ret
 Protein Family    Retbindin
 UniProt Gene Name    RET [Similar Products]
 UniProt Synonym Gene Names    CDHF12; CDHR16; PTC; RET51 [Similar Products]
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 NCBI Summary for RET    This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RET    Ret: a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ret family; TK group

Chromosomal Location of Human Ortholog: 10q11.21

Cellular Component: cytoplasm; endosome membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; receptor complex

Molecular Function: calcium ion binding; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: MAPKKK cascade; membrane protein proteolysis; neuron adhesion; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; posterior midgut development; protein amino acid phosphorylation; regulation of cell adhesion; response to pain; signal transduction

Disease: Hirschsprung Disease, Susceptibility To, 1; Multiple Endocrine Neoplasia, Type Iia; Multiple Endocrine Neoplasia, Type Iib; Thyroid Carcinoma, Familial Medullary; Thyroid Carcinoma, Papillary
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 Research Articles on RET    1. Brazilian and Greek patients with multiple endocrine neoplasia 2A carrying the same mutation in RET gene originate from a common ancestor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RET antibodyPathways associated with anti-RET antibody
 Reference Product  PubMed Publications
 GDNF antibody  >924 publications with RET and GDNF
 GFRA1 antibody  >225 publications with RET and GFRA1
 NRTN antibody  >105 publications with RET and NRTN
 SRC antibody  >85 publications with RET and SRC
 GRB2 antibody  >30 publications with RET and GRB2
 STAT3 antibody  >27 publications with RET and STAT3
 MAPK1 antibody  >27 publications with RET and MAPK1
 MAPK3 antibody  >23 publications with RET and MAPK3
 SHC1 antibody  >23 publications with RET and SHC1
 FRS2 antibody  >10 publications with RET and FRS2
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
Diseases associated with anti-RET antibodyOrgans/Tissues associated with anti-RET antibody
 Disease Name  Pubmed Publications
 Thyroid Neoplasms Antibodies  >1757 publications with RET and Thyroid Neoplasms
 Multiple Endocrine Neoplasia Antibodies  >1188 publications with RET and Multiple Endocrine Neoplasia
 Carcinoma, Medullary Antibodies  >1145 publications with RET and Carcinoma, Medullary
 Adenocarcinoma Antibodies  >938 publications with RET and Adenocarcinoma
 Multiple Endocrine Neoplasia Type 2a Antibodies  >801 publications with RET and Multiple Endocrine Neoplasia Type 2a
 Pheochromocytoma Antibodies  >551 publications with RET and Pheochromocytoma
 Hirschsprung Disease Antibodies  >424 publications with RET and Hirschsprung Disease
 Multiple Endocrine Neoplasia Type 2b Antibodies  >412 publications with RET and Multiple Endocrine Neoplasia Type 2b
 Nervous System Diseases Antibodies  >378 publications with RET and Nervous System Diseases
 Hyperplasia Antibodies  >278 publications with RET and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >753 publications with RET and Nerve
 Blood Antibodies  >709 publications with RET and Blood
 Brain Antibodies  >432 publications with RET and Brain
 Adrenal Gland Antibodies  >318 publications with RET and Adrenal Gland
 Kidney Antibodies  >309 publications with RET and Kidney
 Embryonic Tissue Antibodies  >184 publications with RET and Embryonic Tissue
 Eye Antibodies  >156 publications with RET and Eye
 Liver Antibodies  >127 publications with RET and Liver
 Heart Antibodies  >89 publications with RET and Heart
 Testis Antibodies  >57 publications with RET and Testis
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