Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow RET  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • N-Acetyl Cysteine, Conjugated Antibody
 • Cardiac Troponin T (cTn-T) ELISA Kit
 • Mucin 3B (MUC3B) Recombinant Protein
 • MAGEB2 Antibody
 • Prostaglandin I2 (PGI2) ELISA Kit
 • HIV-1 Recombinant Protein
 • platelet-derived growth factor-BB (PDGF-BB) ELISA Kit
 • TAS1R2 Antibody
 • SOX9 Antibody
 • ZIP8 (Slc39a8) Antibody
 • BIRC2 - cIAP1 Antibody
 • Neprilysin (MME) ELISA Kit
 • RANTES (Ccl5) Recombinant Protein
 • inducible nitric oxide synthase, iNOS-NOS2 ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-RET antibody :: Ret Antibody

Scan QR to view Datasheet Catalog #    MBS8511304
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ret, Antibody

★Popular Item★
 Also Known As   

Phospho-Ret (Tyr1062) Antibody

 Product Synonym Names    C-ret; EC 2.7.10.1; Proto-oncogene ret precursor; kinase Ret
 Product Gene Name   

anti-RET antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    114500
 3D Structure    ModBase 3D Structure for P07949
Section Bar
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    Phospho-Ret (Tyr1062) Antibody detects endogenous levels of Ret only when phosphorylated at Tyrosine 1062
 Purity/Purification    Immunogen affinity purified
 Form/Format    In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Section Bar
 Immunogen    A synthesized peptide derived from human Ret around the phosphorylation site of Tyrosine 1062
Section Bar
 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-RET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-RET antibody

   This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.
 Applications Tested/Suitable for anti-RET antibody   

Western Blot (WB)

 Application Notes for anti-RET antibody    WB: 1:500-1:2000
Section Bar
 Western Blot (WB) of anti-RET antibody    Western blot analysis of Ret phosphorylation expression in K562 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
anti-RET antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for RET. It may not necessarily be applicable to this product.
 NCBI GI #    10862701
 NCBI GeneID    5979
 NCBI Accession #    NP_065681.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020630.5 [Other Products]
Section Bar
 UniProt Primary Accession #    P07949 [Other Products]
 UniProt Secondary Accession #    Q15250; Q9BTB0; Q9H4A2; A8K6Z2 [Other Products]
 UniProt Related Accession #    P07949 [Other Products]
 Molecular Weight    175kDa
Table BarTOPTable Bar
 NCBI Official Full Name    proto-oncogene tyrosine-protein kinase receptor Ret isoform c
 NCBI Official Synonym Full Names    ret proto-oncogene
 NCBI Official Symbol    RET [Similar Products]
 NCBI Official Synonym Symbols   
PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase receptor Ret
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase receptor Ret
 UniProt Synonym Protein Names   
Cadherin family member 12; Proto-oncogene c-Ret
 Protein Family    Retbindin
 UniProt Gene Name    RET [Similar Products]
 UniProt Synonym Gene Names    CDHF12; CDHR16; PTC; RET51 [Similar Products]
Section Bar
 NCBI Summary for RET    This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Section Bar
 UniProt Comments for RET    Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Table BarTOPTable Bar
 Research Articles on RET    1. RET knockdown significantly decreased xenografts tumor growth in vivo, confirming the oncogenic impact of RET signaling in vivo.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-RET antibodyPathways associated with anti-RET antibody
 Reference Product  PubMed Publications
 GDNF antibody  >924 publications with RET and GDNF
 GFRA1 antibody  >225 publications with RET and GFRA1
 NRTN antibody  >105 publications with RET and NRTN
 SRC antibody  >85 publications with RET and SRC
 GRB2 antibody  >30 publications with RET and GRB2
 STAT3 antibody  >27 publications with RET and STAT3
 MAPK1 antibody  >27 publications with RET and MAPK1
 MAPK3 antibody  >23 publications with RET and MAPK3
 SHC1 antibody  >23 publications with RET and SHC1
 FRS2 antibody  >10 publications with RET and FRS2
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
Diseases associated with anti-RET antibodyOrgans/Tissues associated with anti-RET antibody
 Disease Name  Pubmed Publications
 Thyroid Neoplasms Antibodies  >1757 publications with RET and Thyroid Neoplasms
 Multiple Endocrine Neoplasia Antibodies  >1188 publications with RET and Multiple Endocrine Neoplasia
 Carcinoma, Medullary Antibodies  >1145 publications with RET and Carcinoma, Medullary
 Adenocarcinoma Antibodies  >938 publications with RET and Adenocarcinoma
 Multiple Endocrine Neoplasia Type 2a Antibodies  >801 publications with RET and Multiple Endocrine Neoplasia Type 2a
 Pheochromocytoma Antibodies  >551 publications with RET and Pheochromocytoma
 Hirschsprung Disease Antibodies  >424 publications with RET and Hirschsprung Disease
 Multiple Endocrine Neoplasia Type 2b Antibodies  >412 publications with RET and Multiple Endocrine Neoplasia Type 2b
 Nervous System Diseases Antibodies  >378 publications with RET and Nervous System Diseases
 Hyperplasia Antibodies  >278 publications with RET and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >753 publications with RET and Nerve
 Blood Antibodies  >709 publications with RET and Blood
 Brain Antibodies  >432 publications with RET and Brain
 Adrenal Gland Antibodies  >318 publications with RET and Adrenal Gland
 Kidney Antibodies  >309 publications with RET and Kidney
 Embryonic Tissue Antibodies  >184 publications with RET and Embryonic Tissue
 Eye Antibodies  >156 publications with RET and Eye
 Liver Antibodies  >127 publications with RET and Liver
 Heart Antibodies  >89 publications with RET and Heart
 Testis Antibodies  >57 publications with RET and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions