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anti-RARA antibody :: Rabbit Retinoic Acid Receptor alpha Antibody

Scan QR to view Datasheet Catalog #    MBS851138
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinoic Acid Receptor alpha (RARA), Antibody

★Popular Item★
 Also Known As   

Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody

 Product Synonym Names    Retinoic Acid Receptor a (Phospho-Ser77) Antibody; NR1B1; RAR-alpha; Retinoic acid receptor alpha; retinoic acid receptor; alpha; RRA
 Product Gene Name   

anti-RARA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612376
 3D Structure    ModBase 3D Structure for P10276
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Retinoic Acid Receptor alpha (Phospho-Ser77) antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at serine 77.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody againstnon-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of serine 77 (P-P-SP-P-P).
 All Sites    Human: Ser77; Mouse: Ser77; Rat: Ser74
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-RARA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RARA antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-RARA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-RARA antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:5000
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 Testing Data of anti-RARA antibody    P-peptide - +
anti-RARA antibody Testing Data image
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 Testing Data #2 of anti-RARA antibody    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor alpha (Phospho-Ser77) antibody.
Western blot analysis of extracts from Jurkat cells treated with PMA (125ng/ml, 30mins), using Retinoic Acid Receptor alpha (Phospho-Ser77) antibody.
anti-RARA antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for RARA. It may not necessarily be applicable to this product.
 NCBI GI #    4506419
 NCBI GeneID    5914
 NCBI Accession #    NP_000955.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000964.3 [Other Products]
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 UniProt Primary Accession #    P10276 [Other Products]
 UniProt Secondary Accession #    P78456; Q13440; Q13441; Q96S41; Q9NQS0; B8Y636 [Other Products]
 UniProt Related Accession #    P10276 [Other Products]
 Molecular Weight    39,700 Da [Similar Products]
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 NCBI Official Full Name    retinoic acid receptor alpha isoform 1
 NCBI Official Synonym Full Names    retinoic acid receptor, alpha
 NCBI Official Symbol    RARA [Similar Products]
 NCBI Official Synonym Symbols   
RAR; NR1B1
[Similar Products]
 NCBI Protein Information    retinoic acid receptor alpha; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
 UniProt Protein Name    Retinoic acid receptor alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group B member 1
 Protein Family    Retinoic acid receptor
 UniProt Gene Name    RARA [Similar Products]
 UniProt Synonym Gene Names    NR1B1; RAR-alpha [Similar Products]
 UniProt Entry Name    RARA_HUMAN
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 NCBI Summary for RARA    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
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 UniProt Comments for RARA    RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described.

Protein type: Transcription factor; DNA-binding; Oncoprotein; Nuclear receptor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; cell surface; cell soma; perinuclear region of cytoplasm; cytoplasm; nuclear chromatin; dendrite; nucleus; actin cytoskeleton

Molecular Function: protein kinase B binding; protein domain specific binding; retinoic acid binding; zinc ion binding; chromatin DNA binding; transcription coactivator activity; translation repressor activity, nucleic acid binding; phosphoinositide 3-kinase regulator activity; drug binding; alpha-actinin binding; transcription factor binding; protein binding; enzyme binding; protein heterodimerization activity; protein kinase A binding; steroid hormone receptor activity; mRNA 5'-UTR binding; retinoic acid receptor activity; transcription factor activity; transcription corepressor activity; receptor binding

Biological Process: prostate gland development; negative regulation of translational initiation; regulation of myelination; estrogen receptor signaling pathway; glandular epithelial cell development; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; female pregnancy; regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; response to vitamin A; germ cell development; Sertoli cell fate commitment; positive regulation of T-helper 2 cell differentiation; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; response to ethanol; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; limb development; retinoic acid receptor signaling pathway; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; negative regulation of granulocyte differentiation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; ureteric bud development; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; transmembrane transport; positive regulation of interleukin-5 production; transcription initiation from RNA polymerase II promoter; response to retinoic acid; multicellular organism growth; negative regulation of tumor necrosis factor production; positive regulation of binding; liver development; embryonic camera-type eye development; positive regulation of protein kinase B signaling cascade; response to cytokine stimulus; neural tube closure; gene expression; spermatogenesis; positive regulation of neuron differentiation; apoptotic cell clearance

Disease: Acute Promyelocytic Leukemia
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Product References and Citations for anti-RARA antibody

   Giguere V., Nature 330:624-629(1987).
Chen Z., Proc. Natl. Acad. Sci. U.S.A. 91:1178-1182(1994).
Hjalt T.A.H., Mamm. Genome 10:528-529(1999).
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 Research Articles on RARA    1. SUMO-1 modification of RARA is a potent mechanism for balancing proliferation and differentiation by controlling the stability of RARA in cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RARA antibodyPathways associated with anti-RARA antibody
 Reference Product  PubMed Publications
 PML antibody  >420 publications with RARA and PML
 RXRA antibody  >12 publications with RARA and RXRA
 SRC antibody  >2 publications with RARA and SRC
 PRKCA antibody  >1 publications with RARA and PRKCA
 NCOA3 antibody  >1 publications with RARA and NCOA3
 NCOR1 antibody  >1 publications with RARA and NCOR1
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with anti-RARA antibodyOrgans/Tissues associated with anti-RARA antibody
 Disease Name  Pubmed Publications
 Leukemia, Promyelocytic, Acute Antibodies  >374 publications with RARA and Leukemia, Promyelocytic, Acute
 Kidney Diseases Antibodies  >124 publications with RARA and Kidney Diseases
 Disease Models, Animal Antibodies  >39 publications with RARA and Disease Models, Animal
 Breast Neoplasms Antibodies  >24 publications with RARA and Breast Neoplasms
 Nervous System Diseases Antibodies  >16 publications with RARA and Nervous System Diseases
 Adenocarcinoma Antibodies  >12 publications with RARA and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >11 publications with RARA and Neoplasms, Experimental
 Neoplasms, Second Primary Antibodies  >10 publications with RARA and Neoplasms, Second Primary
 Cardiovascular Diseases Antibodies  >9 publications with RARA and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >9 publications with RARA and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >215 publications with RARA and Blood
 Kidney Antibodies  >195 publications with RARA and Kidney
 Bone Antibodies  >141 publications with RARA and Bone
 Bone Marrow Antibodies  >131 publications with RARA and Bone Marrow
 Vascular Antibodies  >49 publications with RARA and Vascular
 Liver Antibodies  >25 publications with RARA and Liver
 Skin Antibodies  >24 publications with RARA and Skin
 Embryonic Tissue Antibodies  >21 publications with RARA and Embryonic Tissue
 Brain Antibodies  >21 publications with RARA and Brain
 Lung Antibodies  >18 publications with RARA and Lung
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