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anti-RRA antibody :: Retinoic Acid Receptor alpha Antibody

Scan QR to view Datasheet Catalog #    MBS851138
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinoic Acid Receptor alpha (RRA), Antibody

★Popular Item★
 Also Known As   

Retinoic Acid Receptor alpha (Phospho-Ser77)Antibody

 Product Synonym Names    NR1B1; RAR-alpha; Retinoic acid receptor alpha; retinoic acid receptor; alpha
 Product Gene Name   

anti-RRA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180240
 3D Structure    ModBase 3D Structure for P10276
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Retinoic Acid Receptor alpha (Phospho-Ser77) antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at serine 77.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody againstnon-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of serine 77 (P-P-SP-P-P).
 All Sites    Human: Ser77
Mouse: Ser77
Rat: Ser74
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-RRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RRA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-RRA antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000
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 Testing Data of anti-RRA antibody    P-peptide-+
anti-RRA antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-RRA antibody    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor alpha (Phospho-Ser77) antibody. Western blot analysis of extracts from Jurkat cells treated with PMA (125ng/ml, 30mins), using Retinoic Acid Receptor alpha (Phospho-Ser77) antibody.
anti-RRA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RRA. It may not necessarily be applicable to this product.
 NCBI GI #    4506419
 NCBI GeneID    5914
 NCBI Accession #    NP_000955.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000964.3 [Other Products]
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 UniProt Primary Accession #    P10276 [Other Products]
 UniProt Secondary Accession #    P78456; Q13440; Q13441; Q96S41; Q9NQS0; B8Y636 [Other Products]
 UniProt Related Accession #    P10276 [Other Products]
 Molecular Weight    39,700 Da
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 NCBI Official Full Name    retinoic acid receptor alpha isoform 1
 NCBI Official Synonym Full Names    retinoic acid receptor alpha
 NCBI Official Symbol    RARA [Similar Products]
 NCBI Official Synonym Symbols   
RAR; NR1B1
[Similar Products]
 NCBI Protein Information    retinoic acid receptor alpha
 UniProt Protein Name    Retinoic acid receptor alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group B member 1
 Protein Family    Retinoic acid receptor
 UniProt Gene Name    RARA [Similar Products]
 UniProt Synonym Gene Names    NR1B1; RAR-alpha [Similar Products]
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 NCBI Summary for RRA    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
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 UniProt Comments for RRA    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function ().
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Product References and Citations for anti-RRA antibody

   Giguere V., Nature 330:624-629(1987). Chen Z., Proc. Natl. Acad. Sci. U.S.A. 91:1178-1182(1994). Hjalt T.A.H., Mamm. Genome 10:528-529(1999).
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 Research Articles on RRA    1. These results therefore indicate that EGCG targets PML/RARalpha oncoprotein for degradation and potentiates differentiation of promyelocytic leukemia cells in combination with ATRA via PTEN.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RRA antibodyPathways associated with anti-RRA antibody
 Reference Product  PubMed Publications
 PML antibody  >366 publications with RRA and PML
 ZBTB16 antibody  >10 publications with RRA and ZBTB16
 RXRA antibody  >8 publications with RRA and RXRA
 STAT5B antibody  >8 publications with RRA and STAT5B
 RXRB antibody  >4 publications with RRA and RXRB
 TRIM24 antibody  >3 publications with RRA and TRIM24
 MED1 antibody  >2 publications with RRA and MED1
 ESR1 antibody  >2 publications with RRA and ESR1
 SP1 antibody  >2 publications with RRA and SP1
 PRKCA antibody  >1 publications with RRA and PRKCA
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with anti-RRA antibodyOrgans/Tissues associated with anti-RRA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >408 publications with RRA and Neoplasms
 Leukemia, Promyelocytic, Acute Antibodies  >326 publications with RRA and Leukemia, Promyelocytic, Acute
 Kidney Diseases Antibodies  >123 publications with RRA and Kidney Diseases
 Proteinuria Antibodies  >80 publications with RRA and Proteinuria
 Breast Neoplasms Antibodies  >19 publications with RRA and Breast Neoplasms
 Drug Toxicity Antibodies  >17 publications with RRA and Drug Toxicity
 Nervous System Diseases Antibodies  >11 publications with RRA and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >11 publications with RRA and Neoplasms, Experimental
 Neoplasms, Second Primary Antibodies  >10 publications with RRA and Neoplasms, Second Primary
 Adenocarcinoma Antibodies  >9 publications with RRA and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >193 publications with RRA and Kidney
 Blood Antibodies  >193 publications with RRA and Blood
 Bone Antibodies  >125 publications with RRA and Bone
 Bone Marrow Antibodies  >116 publications with RRA and Bone Marrow
 Vascular Antibodies  >49 publications with RRA and Vascular
 Skin Antibodies  >22 publications with RRA and Skin
 Embryonic Tissue Antibodies  >21 publications with RRA and Embryonic Tissue
 Liver Antibodies  >19 publications with RRA and Liver
 Brain Antibodies  >18 publications with RRA and Brain
 Lung Antibodies  >16 publications with RRA and Lung
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