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anti-Rheb antibody :: Rabbit Rheb Antibody

Scan QR to view Datasheet Catalog #    MBS854642
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rheb, Antibody

 Also Known As   

Rheb Antibody

 Product Gene Name   

anti-Rheb antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601293
 3D Structure    ModBase 3D Structure for Q15382
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 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse, Monkey
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 Pathway    mTOR signaling pathway
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 Other Notes    Small volumes of anti-Rheb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Rheb antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Rheb antibody   

Western Blot (WB), Immunoprecipitation (IP)

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 Western Blot of anti-Rheb antibody    Western blot analysis of protein extracts from 293 cells overexpressing a mouse Rheb cDNA. The primary antibody was diluted 1:2000 before applied to the blotting membrane. (Right Panel: a schematic illustration of 17 mTOR signaling pathway.)
anti-Rheb antibody Western Blot (WB) image
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 Testing Data of anti-Rheb antibody    anti-Rheb antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Rheb. It may not necessarily be applicable to this product.
 NCBI GI #    5032041
 NCBI GeneID    6009
 NCBI Accession #    NP_005605.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005614.3 [Other Products]
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 UniProt Primary Accession #    Q15382 [Other Products]
 UniProt Secondary Accession #    Q53Y56; Q99444; B3KWN6; D3DX13 [Other Products]
 UniProt Related Accession #    Q15382 [Other Products]
 Molecular Weight    20,497 Da
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 NCBI Official Full Name    GTP-binding protein Rheb
 NCBI Official Synonym Full Names    Ras homolog enriched in brain
 NCBI Official Symbol    RHEB [Similar Products]
 NCBI Official Synonym Symbols   
RHEB2
[Similar Products]
 NCBI Protein Information    GTP-binding protein Rheb; Ras homolog enriched in brain 2
 UniProt Protein Name    GTP-binding protein Rheb
 UniProt Synonym Protein Names   
Ras homolog enriched in brain
 Protein Family    Rheb-like protein
 UniProt Gene Name    RHEB [Similar Products]
 UniProt Synonym Gene Names    RHEB2 [Similar Products]
 UniProt Entry Name    RHEB_HUMAN
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 NCBI Summary for Rheb    This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Rheb    RHEB: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Ubiquitous. Highest levels observed in skeletal and cardiac muscle. Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2. Belongs to the small GTPase superfamily. Rheb family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rheb

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: Golgi membrane; spliceosome; endoplasmic reticulum membrane; membrane; cell soma; dendrite; plasma membrane; cytosol

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; metal ion binding; protein kinase binding

Biological Process: metabolic process; small GTPase mediated signal transduction; insulin receptor signaling pathway; signal transduction; cell cycle arrest; positive regulation of TOR signaling pathway
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 Research Articles on Rheb    1. In vitro data indicated that miR-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of Pseudomonas aeruginosa by targeting Rheb (Ras homolog enriched in brain).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Rheb antibodyPathways associated with anti-Rheb antibody
 Reference Product  PubMed Publications
 MTOR antibody  >285 publications with Rheb and MTOR
 TSC2 antibody  >162 publications with Rheb and TSC2
 TSC1 antibody  >150 publications with Rheb and TSC1
 EIF4EBP1 antibody  >23 publications with Rheb and EIF4EBP1
 RPTOR antibody  >22 publications with Rheb and RPTOR
 MLST8 antibody  >6 publications with Rheb and MLST8
 RPS6KB1 antibody  >2 publications with Rheb and RPS6KB1
 RAF1 antibody  >1 publications with Rheb and RAF1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
Diseases associated with anti-Rheb antibodyOrgans/Tissues associated with anti-Rheb antibody
 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >16 publications with Rheb and Hypertrophy
 Disease Models, Animal Antibodies  >15 publications with Rheb and Disease Models, Animal
 Kidney Diseases Antibodies  >13 publications with Rheb and Kidney Diseases
 Breast Neoplasms Antibodies  >9 publications with Rheb and Breast Neoplasms
 Epilepsy Antibodies  >8 publications with Rheb and Epilepsy
 Cardiovascular Diseases Antibodies  >8 publications with Rheb and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >7 publications with Rheb and Adenocarcinoma
 Atrophy Antibodies  >6 publications with Rheb and Atrophy
 Seizures Antibodies  >5 publications with Rheb and Seizures
 Inflammation Antibodies  >4 publications with Rheb and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >142 publications with Rheb and Brain
 Kidney Antibodies  >29 publications with Rheb and Kidney
 Vascular Antibodies  >14 publications with Rheb and Vascular
 Liver Antibodies  >14 publications with Rheb and Liver
 Lung Antibodies  >12 publications with Rheb and Lung
 Skin Antibodies  >12 publications with Rheb and Skin
 Eye Antibodies  >9 publications with Rheb and Eye
 Embryonic Tissue Antibodies  >6 publications with Rheb and Embryonic Tissue
 Bone Antibodies  >6 publications with Rheb and Bone
 Pancreas Antibodies  >5 publications with Rheb and Pancreas
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