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anti-RhoH antibody :: Rabbit RhoH Antibody

Scan QR to view Datasheet Catalog #    MBS001701 anti-RhoH antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RhoH, Antibody

 Also Known As   

Rabbit RhoH Antibody

 Product Gene Name   

anti-RhoH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (40198527..40246281). Location: 4p13
 OMIM    602037
 3D Structure    ModBase 3D Structure for Q15669
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-RhoH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RhoH antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RhoH. It may not necessarily be applicable to this product.
 NCBI GI #    4757770
 NCBI GeneID    399
 NCBI Accession #    NP_004301.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004310.4 [Other Products]
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 UniProt Primary Accession #    Q15669 [Other Products]
 UniProt Related Accession #    Q15669 [Other Products]
 Molecular Weight    21,331 Da
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 NCBI Official Full Name    rho-related GTP-binding protein RhoH
 NCBI Official Synonym Full Names    ras homolog family member H
 NCBI Official Symbol    RHOH [Similar Products]
 NCBI Official Synonym Symbols   
TTF; ARHH
[Similar Products]
 NCBI Protein Information    rho-related GTP-binding protein RhoH; GTP-binding protein TTF; TTF, translocation three four; ras homolog gene family, member H
 UniProt Protein Name    Rho-related GTP-binding protein RhoH
 UniProt Synonym Protein Names   
GTP-binding protein TTF; Translocation three four protein
 Protein Family    Rho-related GTP-binding protein
 UniProt Gene Name    RHOH [Similar Products]
 UniProt Synonym Gene Names    ARHH; TTF [Similar Products]
 UniProt Entry Name    RHOH_HUMAN
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 NCBI Summary for RhoH    The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]
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 UniProt Comments for RhoH    RHOH: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein; G protein, monomeric, Rho; G protein, monomeric

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: cytoplasm; plasma membrane; immunological synapse; cytosol

Molecular Function: protein binding; Rho GTPase binding; GTP binding; kinase inhibitor activity; GTPase inhibitor activity

Biological Process: regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; negative regulation of catalytic activity; negative regulation of phosphorylation; negative regulation of I-kappaB kinase/NF-kappaB cascade; mast cell activation; T cell differentiation
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 Research Articles on RhoH    1. RHOH deficiency leads to T cell defects and persistent epidermodysplasia verruciformis-HPV infections.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RhoH antibodyPathways associated with anti-RhoH antibody
 Reference Product  PubMed Publications
 ARHGDIB antibody  >1 publications with RhoH and ARHGDIB
 Products by Pathway  Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
Diseases associated with anti-RhoH antibodyOrgans/Tissues associated with anti-RhoH antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with RhoH and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >5 publications with RhoH and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >2 publications with RhoH and Cardiovascular Diseases
 Hepatitis Antibodies  >1 publications with RhoH and Hepatitis
 Thyroid Neoplasms Antibodies  >1 publications with RhoH and Thyroid Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with RhoH and Neoplasms, Experimental
 Fibrosis Antibodies  >1 publications with RhoH and Fibrosis
 Liver Diseases Antibodies  >1 publications with RhoH and Liver Diseases
 Disease Models, Animal Antibodies  >1 publications with RhoH and Disease Models, Animal
 Necrosis Antibodies  >1 publications with RhoH and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with RhoH and Blood
 Bone Marrow Antibodies  >8 publications with RhoH and Bone Marrow
 Spleen Antibodies  >3 publications with RhoH and Spleen
 Lymph Node Antibodies  >3 publications with RhoH and Lymph Node
 Thymus Antibodies  >3 publications with RhoH and Thymus
 Lymph Antibodies  >2 publications with RhoH and Lymph
 Lung Antibodies  >1 publications with RhoH and Lung
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