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anti-S100A8 antibody :: Rabbit S100A8 Antibody

Scan QR to view Datasheet Catalog #    MBS8500947
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100A8, Antibody

★Popular Item★
 Also Known As   

S100A8 Antibody

 Product Synonym Names    60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8
 Product Gene Name   

anti-S100A8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123885
 3D Structure    ModBase 3D Structure for P05109
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human S100A8
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-S100A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-S100A8 antibody

   The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-S100A8 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-S100A8 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-S100A8 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Testing Data of anti-S100A8 antibody    Western blot analysis of extracts of K-562cell lines, using S100A8 antibody.
anti-S100A8 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for S100A8. It may not necessarily be applicable to this product.
 NCBI GI #    984290540
 NCBI GeneID    6279
 NCBI Accession #    NP_001306126.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001319197.1 [Other Products]
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 UniProt Primary Accession #    P05109 [Other Products]
 UniProt Secondary Accession #    Q5SY70; Q9UC84; Q9UC92; Q9UCJ0; Q9UCM6; A8K5L3; D3DV37 [Other Products]
 UniProt Related Accession #    P05109 [Other Products]
 Molecular Weight    11kDa
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 NCBI Official Full Name    protein S100-A8 isoform b
 NCBI Official Synonym Full Names    S100 calcium binding protein A8
 NCBI Official Symbol    S100A8 [Similar Products]
 NCBI Official Synonym Symbols   
P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
[Similar Products]
 NCBI Protein Information    protein S100-A8
 UniProt Protein Name    Protein S100-A8
 UniProt Synonym Protein Names   
Calgranulin-A; Calprotectin L1L subunit; Cystic fibrosis antigen; CFAG; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; p8; S100 calcium-binding protein A8; Urinary stone protein band A
 Protein Family    Protein
 UniProt Gene Name    S100A8 [Similar Products]
 UniProt Synonym Gene Names    CAGA; CFAG; MRP8; CFAG; MRP-8; p8 [Similar Products]
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 NCBI Summary for S100A8    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
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 UniProt Comments for S100A8    S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
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 Research Articles on S100A8    1. S100A8 methylation has a role in diagnosis and prognosis of hepatocellular carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-S100A8 antibodyPathways associated with anti-S100A8 antibody
 Reference Product  PubMed Publications
 S100A9 antibody  >894 publications with S100A8 and S100A9
 TLR4 antibody  >83 publications with S100A8 and TLR4
 MYD88 antibody  >13 publications with S100A8 and MYD88
 SRC antibody  >7 publications with S100A8 and SRC
 MIF antibody  >6 publications with S100A8 and MIF
 BAX antibody  >5 publications with S100A8 and BAX
 TIRAP antibody  >2 publications with S100A8 and TIRAP
 LY96 antibody  >2 publications with S100A8 and LY96
 Products by Pathway  Pathway Diagram
 Antimicrobial Peptides Pathway antibodies  Antimicrobial Peptides Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Metal Sequestration By Antimicrobial Proteins Pathway antibodies  Metal Sequestration By Antimicrobial Proteins Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Regulation Of TLR By Endogenous Ligand Pathway antibodies  Regulation Of TLR By Endogenous Ligand Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
Diseases associated with anti-S100A8 antibodyOrgans/Tissues associated with anti-S100A8 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >535 publications with S100A8 and Inflammation
 Disease Models, Animal Antibodies  >142 publications with S100A8 and Disease Models, Animal
 Fibrosis Antibodies  >112 publications with S100A8 and Fibrosis
 Necrosis Antibodies  >104 publications with S100A8 and Necrosis
 Cardiovascular Diseases Antibodies  >94 publications with S100A8 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >74 publications with S100A8 and Nervous System Diseases
 Atherosclerosis Antibodies  >51 publications with S100A8 and Atherosclerosis
 Heart Diseases Antibodies  >39 publications with S100A8 and Heart Diseases
 Kidney Diseases Antibodies  >36 publications with S100A8 and Kidney Diseases
 Breast Neoplasms Antibodies  >36 publications with S100A8 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >603 publications with S100A8 and Blood
 Skin Antibodies  >165 publications with S100A8 and Skin
 Lung Antibodies  >130 publications with S100A8 and Lung
 Vascular Antibodies  >108 publications with S100A8 and Vascular
 Bone Antibodies  >82 publications with S100A8 and Bone
 Brain Antibodies  >64 publications with S100A8 and Brain
 Bone Marrow Antibodies  >61 publications with S100A8 and Bone Marrow
 Kidney Antibodies  >58 publications with S100A8 and Kidney
 Liver Antibodies  >57 publications with S100A8 and Liver
 Heart Antibodies  >54 publications with S100A8 and Heart
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