NP_000325.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
208,061 Da
NCBI Official Full Name
sodium channel protein type 4 subunit alpha
NCBI Official Synonym Full Names
sodium voltage-gated channel alpha subunit 4
NCBI Official Synonym Symbols
HYPP; SkM1; CMS16; HYKPP; NAC1A; HOKPP2; Nav1.4; Na(V)1.4 [Similar Products]
NCBI Protein Information
sodium channel protein type 4 subunit alpha
UniProt Protein Name
Sodium channel protein type 4 subunit alpha
UniProt Synonym Protein Names
SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4
NCBI Summary for SCN4A
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
UniProt Comments for SCN4A
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
Product References and Citations for anti-SCN4A antibody
George A.L. Jr., Ann. Neurol. 31:131-137(1992). Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992). Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).
Research Articles on SCN4A
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Pathways associated with anti-SCN4A antibody
Diseases associated with anti-SCN4A antibody
Organs/Tissues associated with anti-SCN4A antibody
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