NP_001139501.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,364 Da
NCBI Official Full Name
semaphorin-7A isoform 2
NCBI Official Synonym Full Names
semaphorin 7A (John Milton Hagen blood group)
NCBI Official Synonym Symbols
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1 [Similar Products]
NCBI Protein Information
semaphorin-7A
UniProt Protein Name
Semaphorin-7A
UniProt Synonym Protein Names
CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108
UniProt Synonym Gene Names
NCBI Summary for SEMA7A
This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Comments for SEMA7A
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Product References and Citations for anti-SEMA7A antibody
Lange C., Genomics 51:340-350(1998) [PubMed: 9721204]. Yamada A., J. Immunol. 162:4094-4100(1999) [PubMed: 10201933]. Xu X., J. Biol. Chem. 273:22428-22434(1998) [PubMed: 9712866].
Research Articles on SEMA7A
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Pathways associated with anti-SEMA7A antibody
Diseases associated with anti-SEMA7A antibody
Organs/Tissues associated with anti-SEMA7A antibody
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