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anti-SHH antibody :: Mouse anti-Human SHH Antibody

Scan QR to view Datasheet Catalog #    MBS850560
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHH, Antibody

 Also Known As   

SHH Antibody

 Product Synonym Names    TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; SHH
 Product Gene Name   

anti-SHH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    135750
 3D Structure    ModBase 3D Structure for Q15465
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 Isotype    IgG1
 Clone Number    8G3
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human SHH expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-SHH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SHH antibody

   This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities.
 Product Categories/Family for anti-SHH antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-SHH antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SHH antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Western Blot (WB) of anti-SHH antibody    Figure 1: Western blot analysis using SHH mAb against SHH-hIgGFc transfected HEK293 cell lysate.
anti-SHH antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SHH. It may not necessarily be applicable to this product.
 NCBI GI #    4506939
 NCBI GeneID    6469
 NCBI Accession #    NP_000184.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000193.3 [Other Products]
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 UniProt Primary Accession #    Q15465 [Other Products]
 UniProt Secondary Accession #    Q75MC9; A4D247 [Other Products]
 UniProt Related Accession #    Q15465 [Other Products]
 Molecular Weight    49.6kDa
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 NCBI Official Full Name    sonic hedgehog protein isoform 1 preproprotein
 NCBI Official Synonym Full Names    sonic hedgehog
 NCBI Official Symbol    SHH [Similar Products]
 NCBI Official Synonym Symbols   
TPT; HHG1; HLP3; HPE3; SMMCI; ShhNC; TPTPS; MCOPCB5
[Similar Products]
 NCBI Protein Information    sonic hedgehog protein
 UniProt Protein Name    Sonic hedgehog protein
 UniProt Synonym Protein Names   
Sonic hedgehog protein N-product; ShhN
 Protein Family    Sonic hedgehog protein
 UniProt Gene Name    SHH [Similar Products]
 UniProt Synonym Gene Names    ShhNp [Similar Products]
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 NCBI Summary for SHH    This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SHH    Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (). Both activities occur in the reticulum endoplasmic (). Once cleaved, ShhC is degraded in the endoplasmic reticulum ().
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 Research Articles on SHH    1. Hh signaling activation might reflect aggressive tumoral behavior, since high epithelial GLI2 expression positively correlates with a higher pathological Gleason score. Moreover, higher epithelial GLI3 expression is an independent marker of a more favorable prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHH antibodyPathways associated with anti-SHH antibody
 Reference Product  PubMed Publications
 GLI1 antibody  >818 publications with SHH and GLI1
 PTCH1 antibody  >443 publications with SHH and PTCH1
 GLI3 antibody  >342 publications with SHH and GLI3
 GLI2 antibody  >341 publications with SHH and GLI2
 BMP4 antibody  >270 publications with SHH and BMP4
 BMP2 antibody  >111 publications with SHH and BMP2
 HHIP antibody  >52 publications with SHH and HHIP
 PTCH2 antibody  >36 publications with SHH and PTCH2
 GAS1 antibody  >32 publications with SHH and GAS1
 GPC3 antibody  >4 publications with SHH and GPC3
 Products by Pathway  Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 HHAT G278V Abrogates Palmitoylation Of Hh-Np Pathway antibodies  HHAT G278V Abrogates Palmitoylation Of Hh-Np Pathway Diagram
Diseases associated with anti-SHH antibodyOrgans/Tissues associated with anti-SHH antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >393 publications with SHH and Brain Diseases
 Abnormalities, Multiple Antibodies  >322 publications with SHH and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >258 publications with SHH and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >244 publications with SHH and Craniofacial Abnormalities
 Holoprosencephaly Antibodies  >210 publications with SHH and Holoprosencephaly
 Adenocarcinoma Antibodies  >158 publications with SHH and Adenocarcinoma
 Neural Tube Defects Antibodies  >113 publications with SHH and Neural Tube Defects
 Holoprosencephaly 3 Antibodies  >85 publications with SHH and Holoprosencephaly 3
 Inflammation Antibodies  >83 publications with SHH and Inflammation
 Lung Diseases Antibodies  >76 publications with SHH and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1191 publications with SHH and Brain
 Lung Antibodies  >221 publications with SHH and Lung
 Liver Antibodies  >136 publications with SHH and Liver
 Intestine Antibodies  >88 publications with SHH and Intestine
 Uncharacterized Tissue Antibodies  >2 publications with SHH and Uncharacterized Tissue
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