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anti-SHP-2 antibody :: Rabbit SHP-2 (Ab-580) Antibody

Scan QR to view Datasheet Catalog #    MBS002805 anti-SHP-2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHP-2 (Ab-580), Antibody

 Also Known As   

Rabbit SHP-2 (Ab-580) Antibody

 Product Gene Name   

anti-SHP-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (112856536..112947717). Location: 12q24
 OMIM    151100
 3D Structure    ModBase 3D Structure for Q06124
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-SHP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SHP-2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SHP-2. It may not necessarily be applicable to this product.
 NCBI GI #    33356177
 NCBI GeneID    5781
 NCBI Accession #    NP_002825.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002834.3 [Other Products]
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 UniProt Primary Accession #    Q06124 [Other Products]
 UniProt Secondary Accession #    Q96HD7; A8K1D9 [Other Products]
 UniProt Related Accession #    Q06124 [Other Products]
 Molecular Weight    68,436 Da
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 11 isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 11
 NCBI Official Symbol    PTPN11 [Similar Products]
 NCBI Official Synonym Symbols   
CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 11; PTP-2C; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 11
 UniProt Synonym Protein Names   
Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
 UniProt Gene Name    PTPN11 [Similar Products]
 UniProt Synonym Gene Names    PTP2C; SHPTP2; PTP-1D; PTP-2C; SHP-2; Shp2 [Similar Products]
 UniProt Entry Name    PTN11_HUMAN
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 NCBI Summary for SHP-2    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for SHP-2    SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; phospholipase binding; peptide hormone receptor binding; SH3/SH2 adaptor activity; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; phosphoprotein phosphatase activity; D1 dopamine receptor binding; insulin receptor binding

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; hormone-mediated signaling; activation of MAPK activity; heart development; platelet-derived growth factor receptor signaling pathway; positive regulation of mitotic cell cycle; glucose homeostasis; reproductive process in a multicellular organism; regulation of protein export from nucleus; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; abortive mitotic cell cycle; inner ear development; negative regulation of cell adhesion mediated by integrin; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of growth hormone secretion; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; T cell costimulation; DNA damage checkpoint; insulin receptor signaling pathway; hormone metabolic process; innate immune response; brain development; platelet formation; blood coagulation; leukocyte migration

Disease: Metachondromatosis; Noonan Syndrome 1; Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1
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 Research Articles on SHP-2    1. results indicate that RSK directly phosphorylates Gab2 on 3 serine residues; findings show RSK-mediated Gab2 phosphorylation inhibits Shp2 recruitment, suggesting RSK mediates a negative-feedback loop that attenuates Gab2-dependent functions including cell motility
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHP-2 antibodyPathways associated with anti-SHP-2 antibody
 Reference Product  PubMed Publications
 SRC antibody  >702 publications with SHP-2 and SRC
 PTPN6 antibody  >649 publications with SHP-2 and PTPN6
 GRB2 antibody  >162 publications with SHP-2 and GRB2
 STAT3 antibody  >95 publications with SHP-2 and STAT3
 JAK2 antibody  >93 publications with SHP-2 and JAK2
 GAB1 antibody  >84 publications with SHP-2 and GAB1
 SOS1 antibody  >79 publications with SHP-2 and SOS1
 MAPK3 antibody  >61 publications with SHP-2 and MAPK3
 STAT1 antibody  >51 publications with SHP-2 and STAT1
 cagA antibody  >51 publications with SHP-2 and cagA
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
Diseases associated with anti-SHP-2 antibodyOrgans/Tissues associated with anti-SHP-2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >381 publications with SHP-2 and Neoplasms
 Noonan Syndrome Antibodies  >321 publications with SHP-2 and Noonan Syndrome
 Heart Diseases Antibodies  >320 publications with SHP-2 and Heart Diseases
 Leukemia Antibodies  >234 publications with SHP-2 and Leukemia
 LEOPARD Syndrome Antibodies  >104 publications with SHP-2 and LEOPARD Syndrome
 Leukemia, Myelomonocytic, Juvenile Antibodies  >79 publications with SHP-2 and Leukemia, Myelomonocytic, Juvenile
 Carcinoma Antibodies  >69 publications with SHP-2 and Carcinoma
 Inflammation Antibodies  >56 publications with SHP-2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >53 publications with SHP-2 and Cell Transformation, Neoplastic
 LEOPARD syndrome, 1 Antibodies  >43 publications with SHP-2 and LEOPARD syndrome, 1
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >385 publications with SHP-2 and Blood
 Heart Antibodies  >164 publications with SHP-2 and Heart
 Muscle Antibodies  >112 publications with SHP-2 and Muscle
 Bone Antibodies  >104 publications with SHP-2 and Bone
 Brain Antibodies  >90 publications with SHP-2 and Brain
 Bone Marrow Antibodies  >82 publications with SHP-2 and Bone Marrow
 Liver Antibodies  >58 publications with SHP-2 and Liver
 Skin Antibodies  >52 publications with SHP-2 and Skin
 Nerve Antibodies  >48 publications with SHP-2 and Nerve
 Stomach Antibodies  >46 publications with SHP-2 and Stomach
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