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anti-SLC24A6 antibody :: Rabbit anti-Human SLC24A6 Antibody

Scan QR to view Datasheet Catalog #    MBS004052
Western Blot (WB)
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC24A6, Antibody

★Popular Item★
 Also Known As   

Rabbit SLC24A6 Antibody

 Product Synonym Names    FLJ22233; Na(+)/K(+)/Ca(2+) exchange protein 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; NCKX6; NCKX6_HUMAN; NCLX; Slc24a6; Sodium/potassium/calcium exchanger; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6; Solute carrier family 24 member 6
 Product Gene Name   

anti-SLC24A6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (113736571..113772925, complement). Location: 12q24.13
 OMIM    609841
 3D Structure    ModBase 3D Structure for Q6J4K2
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    SLC24A6 Antibody detects endogenous levels of total SLC24A6
 Purity/Purification    Immunogen affinity purified
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
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 Buffer    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Immunogen    A synthesized peptide
 Function    Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
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 Preparation and Storage    Store at -20 C.Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-SLC24A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Application Notes for anti-SLC24A6 antibody    WB 1:500~1:1000
ELISA(peptide) 1:20000-1:40000

Optimal dilutions/concentrations should be determined by the end user.
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 Western Blot (WB) of anti-SLC24A6 antibody    Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.
anti-SLC24A6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SLC24A6. It may not necessarily be applicable to this product.
 NCBI GI #    39995086
 NCBI GeneID    80024
 NCBI Accession #    NP_079235.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_024959.2 [Other Products]
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 UniProt Primary Accession #    Q6J4K2 [Other Products]
 UniProt Secondary Accession #    Q4KMS9; Q6J4K1; Q9H6I8; A6NP50 [Other Products]
 UniProt Related Accession #    Q6J4K2 [Other Products]
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 NCBI Official Full Name    sodium/potassium/calcium exchanger 6, mitochondrial
 NCBI Official Synonym Full Names    solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
 NCBI Official Symbol    SLC24A6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 member 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; sodium/calcium exchanger protein, mitochondrial; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
 UniProt Protein Name    Sodium/potassium/calcium exchanger 6, mitochondrial
 UniProt Synonym Protein Names   
Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Solute carrier family 24 member 6
 UniProt Gene Name    SLC24A6 [Similar Products]
 UniProt Synonym Gene Names    NCKX6; NCLX [Similar Products]
 UniProt Entry Name    NCKX6_HUMAN
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 NCBI Summary for SLC24A6    SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for SLC24A6    SLC24A6: Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: mitochondrial crista; plasma membrane; sarcolemma

Molecular Function: protein homodimerization activity; calcium:sodium antiporter activity

Biological Process: mitochondrial calcium ion homeostasis; cytosolic calcium ion homeostasis; response to stimulus; ion transport; glucose homeostasis; regulation of insulin secretion; transmembrane transport; mitochondrial calcium ion transport
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 Research Articles on SLC24A6    1. NCLX catalyzes active Li(+)/Ca(2+) exchange.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLC24A6 antibodyOrgans/Tissues associated with anti-SLC24A6 antibody
 Products by Pathway  Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Sodium/Calcium Exchangers Pathway antibodies  Sodium/Calcium Exchangers Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with SLC24A6 and Heart
 Muscle Antibodies  >1 publications with SLC24A6 and Muscle
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