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anti-SLC33A1 antibody :: Rabbit anti-Human SLC33A1 Antibody

Scan QR to view Datasheet Catalog #    MBS004648 anti-SLC33A1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC33A1, Antibody

 Also Known As   

Rabbit SLC33A1 Antibody

 Product Gene Name   

anti-SLC33A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (155544300..155572248, complement). Location: 3q25.31
 OMIM    603690
 3D Structure    ModBase 3D Structure for O00400
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-SLC33A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SLC33A1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SLC33A1. It may not necessarily be applicable to this product.
 NCBI GI #    300360496
 NCBI GeneID    9197
 NCBI Accession #    NP_001177921.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190992.1 [Other Products]
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 UniProt Primary Accession #    O00400 [Other Products]
 UniProt Secondary Accession #    B2R5Q2; D3DNK4 [Other Products]
 UniProt Related Accession #    O00400 [Other Products]
 Molecular Weight    60,909 Da
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 NCBI Official Full Name    acetyl-coenzyme A transporter 1
 NCBI Official Synonym Full Names    solute carrier family 33 (acetyl-CoA transporter), member 1
 NCBI Official Symbol    SLC33A1 [Similar Products]
 NCBI Official Synonym Symbols   
AT1; AT-1; ACATN; SPG42; CCHLND
[Similar Products]
 NCBI Protein Information    acetyl-coenzyme A transporter 1
 UniProt Protein Name    Acetyl-coenzyme A transporter 1
 UniProt Synonym Protein Names   
Solute carrier family 33 member 1
 Protein Family    Acetyl-coenzyme A transporter
 UniProt Gene Name    SLC33A1 [Similar Products]
 UniProt Synonym Gene Names    ACATN; AT1; AT-1 [Similar Products]
 UniProt Entry Name    ACATN_HUMAN
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 NCBI Summary for SLC33A1    The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for SLC33A1    SLC33A1: Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in SLC33A1 are the cause of congenital cataracts, hearing loss, and neurodegeneration (CCHLND). CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Belongs to the SLC33A transporter family.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q25.31

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; integral to plasma membrane

Molecular Function: acetyl-CoA transporter activity; solute:hydrogen symporter activity

Biological Process: proton transport; acetyl-CoA transport; transport; transmembrane transport

Disease: Spastic Paraplegia 42, Autosomal Dominant; Congenital Cataracts, Hearing Loss, And Neurodegeneration
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 Research Articles on SLC33A1    1. IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLC33A1 antibodyDiseases associated with anti-SLC33A1 antibody
 Products by Pathway  Pathway Diagram
 Ganglio Sphingolipid Metabolism Pathway antibodies  Ganglio Sphingolipid Metabolism Pathway Diagram
 Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies  Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies  Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Vitamins, Nucleosides, And Related Molecules Pathway antibodies  Transport Of Vitamins, Nucleosides, And Related Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with SLC33A1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >1 publications with SLC33A1 and Liver Neoplasms
Organs/Tissues associated with anti-SLC33A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with SLC33A1 and Brain
 Embryonic Tissue Antibodies  >2 publications with SLC33A1 and Embryonic Tissue
 Liver Antibodies  >1 publications with SLC33A1 and Liver
 Skin Antibodies  >1 publications with SLC33A1 and Skin
 Blood Antibodies  >1 publications with SLC33A1 and Blood
 Bladder Antibodies  >1 publications with SLC33A1 and Bladder
 Muscle Antibodies  >1 publications with SLC33A1 and Muscle
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