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anti-SNAI1 antibody :: Rabbit anti-Human, mouse SNAI1 (Ab-246) Antibody

Scan QR to view Datasheet Catalog #    MBS000031 anti-SNAI1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SNAI1 (Ab-246), Antibody

★Popular Item★
 Also Known As   

Rabbit SNAI1 (Ab-246) Antibody

 Product Gene Name   

anti-SNAI1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (48599513..48605423). Location: 20q13.2
 OMIM    604238
 3D Structure    ModBase 3D Structure for O95863
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-SNAI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SNAI1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SNAI1. It may not necessarily be applicable to this product.
 NCBI GI #    18765741
 NCBI GeneID    6615
 NCBI Accession #    NP_005976.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005985.3 [Other Products]
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 UniProt Primary Accession #    O95863 [Other Products]
 UniProt Secondary Accession #    Q9P113; Q9UBP7; Q9UHH7; B2R842 [Other Products]
 UniProt Related Accession #    O95863 [Other Products]
 Molecular Weight    29,083 Da
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 NCBI Official Full Name    zinc finger protein SNAI1
 NCBI Official Synonym Full Names    snail family zinc finger 1
 NCBI Official Symbol    SNAI1 [Similar Products]
 NCBI Official Synonym Symbols   
SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1
[Similar Products]
 NCBI Protein Information    zinc finger protein SNAI1; protein sna; snail 1 homolog; snail homolog 1; protein snail homolog 1; snail 1 zinc finger protein; snail 1, zinc finger protein
 UniProt Protein Name    Zinc finger protein SNAI1
 UniProt Synonym Protein Names   
Protein snail homolog 1
 Protein Family    Protein snail
 UniProt Gene Name    SNAI1 [Similar Products]
 UniProt Synonym Gene Names    SNAH; Protein sna [Similar Products]
 UniProt Entry Name    SNAI1_HUMAN
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 NCBI Summary for SNAI1    The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SNAI1    Snail1: a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT.

Protein type: Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell migration; hair follicle morphogenesis; mesoderm formation; positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; palate development; positive regulation of cell migration
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 Research Articles on SNAI1    1. Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SNAI1 antibodyDiseases associated with anti-SNAI1 antibody
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway antibodies  Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >71 publications with SNAI1 and Neoplasms
 Neoplasm Invasiveness Antibodies  >27 publications with SNAI1 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >23 publications with SNAI1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >22 publications with SNAI1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >16 publications with SNAI1 and Lung Neoplasms
 Lung Diseases Antibodies  >15 publications with SNAI1 and Lung Diseases
 Disease Models, Animal Antibodies  >9 publications with SNAI1 and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >9 publications with SNAI1 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >7 publications with SNAI1 and Cell Transformation, Neoplastic
 Melanoma Antibodies  >7 publications with SNAI1 and Melanoma
Organs/Tissues associated with anti-SNAI1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >27 publications with SNAI1 and Lung
 Embryonic Tissue Antibodies  >23 publications with SNAI1 and Embryonic Tissue
 Bone Antibodies  >14 publications with SNAI1 and Bone
 Skin Antibodies  >9 publications with SNAI1 and Skin
 Vascular Antibodies  >9 publications with SNAI1 and Vascular
 Brain Antibodies  >6 publications with SNAI1 and Brain
 Blood Antibodies  >5 publications with SNAI1 and Blood
 Pancreas Antibodies  >5 publications with SNAI1 and Pancreas
 Kidney Antibodies  >4 publications with SNAI1 and Kidney
 Intestine Antibodies  >3 publications with SNAI1 and Intestine
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