NP_003736.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
suppressor of cytokine signaling 1
NCBI Official Synonym Full Names
suppressor of cytokine signaling 1
NCBI Official Synonym Symbols
JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1 [Similar Products]
NCBI Protein Information
suppressor of cytokine signaling 1; TIP-3; OTTHUMP00000160221; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1
UniProt Protein Name
Suppressor of cytokine signaling 1
UniProt Synonym Protein Names
JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3
UniProt Synonym Gene Names
UniProt Entry Name
SOCS1_HUMAN
NCBI Summary for SOCS1
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq]
UniProt Comments for SOCS1
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival
By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. Ref.7 Ref.8
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV
By similarity. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1
By similarity. Interacts (via SH2 domain and SOCS box) with TRIM8
By similarity. Interacts with CUL2. Ref.7
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Induction: By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.
Domain: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box
Sequence similarities: Contains 1 SH2 domain.Contains 1 SOCS box domain.
Product References and Citations for anti-SOCS1 antibody
Hongwei Qin, et al. IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia. The FASEB Journal. 2006;20:985-987.
Research Articles on SOCS1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-SOCS1 antibody
Pathways associated with anti-SOCS1 antibody
Diseases associated with anti-SOCS1 antibody
Organs/Tissues associated with anti-SOCS1 antibody
|