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anti-SORL1 antibody :: Mouse anti-Human SORL1 Antibody

Scan QR to view Datasheet Catalog #    MBS850606
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SORL1, Antibody

 Also Known As   

SORL1 Antibody

 Product Synonym Names    SORL1
 Product Gene Name   

anti-SORL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104300
 3D Structure    ModBase 3D Structure for Q92673
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 Isotype    IgG
 Clone Number    7D7B11
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-SORL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SORL1 antibody

   SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
 Product Categories/Family for anti-SORL1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-SORL1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SORL1 antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Western Blot (WB) of anti-SORL1 antibody    Figure 1. Western blot analysis using SORL1 mouse mAb against truncated SORL1 recombinant protein (1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2).
anti-SORL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SORL1. It may not necessarily be applicable to this product.
 NCBI GI #    4507157
 NCBI GeneID    6653
 NCBI Accession #    NP_003096.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003105.5 [Other Products]
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 UniProt Primary Accession #    Q92673 [Other Products]
 UniProt Secondary Accession #    Q92856; B2RNX7 [Other Products]
 UniProt Related Accession #    Q92673 [Other Products]
 Molecular Weight    248,426 Da
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 NCBI Official Full Name    sortilin-related receptor preproprotein
 NCBI Official Synonym Full Names    sortilin related receptor 1
 NCBI Official Symbol    SORL1 [Similar Products]
 NCBI Official Synonym Symbols   
LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32
[Similar Products]
 NCBI Protein Information    sortilin-related receptor
 UniProt Protein Name    Sortilin-related receptor
 UniProt Synonym Protein Names   
Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA
 Protein Family    Sortilin-related receptor
 UniProt Gene Name    SORL1 [Similar Products]
 UniProt Synonym Gene Names    C11orf32; LDLR relative with 11 ligand-binding repeats; LR11; SorLA [Similar Products]
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 NCBI Summary for SORL1    This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
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 UniProt Comments for SORL1    Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
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 Research Articles on SORL1    1. We conclude that rs1784933 and rs1805192 minor alleles, gene- gene interaction between rs1784933 and rs1805192, gene- environment interaction between rs1784933 and alcohol drinking, and haplotype containing the rs1784933- A and rs689021- C alleles are all associated with increased LOAD risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SORL1 antibodyDiseases associated with anti-SORL1 antibody
 Reference Product  PubMed Publications
 BACE1 antibody  >9 publications with SORL1 and BACE1
 FURIN antibody  >4 publications with SORL1 and FURIN
 GGA1 antibody  >2 publications with SORL1 and GGA1
 OPCML antibody  >1 publications with SORL1 and OPCML
 GGA2 antibody  >1 publications with SORL1 and GGA2
 Disease Name  Pubmed Publications
 Alzheimer Disease Antibodies  >104 publications with SORL1 and Alzheimer Disease
 Nervous System Diseases Antibodies  >103 publications with SORL1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >15 publications with SORL1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >13 publications with SORL1 and Atherosclerosis
 Disease Models, Animal Antibodies  >10 publications with SORL1 and Disease Models, Animal
 Nerve Degeneration Antibodies  >5 publications with SORL1 and Nerve Degeneration
 Heart Diseases Antibodies  >4 publications with SORL1 and Heart Diseases
 Necrosis Antibodies  >4 publications with SORL1 and Necrosis
 Hyperplasia Antibodies  >3 publications with SORL1 and Hyperplasia
 Inflammation Antibodies  >2 publications with SORL1 and Inflammation
Organs/Tissues associated with anti-SORL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >81 publications with SORL1 and Brain
 Blood Antibodies  >27 publications with SORL1 and Blood
 Nerve Antibodies  >20 publications with SORL1 and Nerve
 Vascular Antibodies  >19 publications with SORL1 and Vascular
 Muscle Antibodies  >14 publications with SORL1 and Muscle
 Kidney Antibodies  >9 publications with SORL1 and Kidney
 Liver Antibodies  >7 publications with SORL1 and Liver
 Heart Antibodies  >6 publications with SORL1 and Heart
 Embryonic Tissue Antibodies  >4 publications with SORL1 and Embryonic Tissue
 Lung Antibodies  >3 publications with SORL1 and Lung
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