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anti-SOX-2 antibody :: Rabbit SOX-2 Antibody

Scan QR to view Datasheet Catalog #    MBS462135
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX-2, Antibody

★Popular Item★
 Also Known As   

Rabbit anti SOX-2 antibody

 Product Synonym Names    Rabbit anti-SOX-2; Sry-related high-mobility group (HMG) box 2
 Product Gene Name   

anti-SOX-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (181429722..181432224). Location: 3q26.3-q27
 OMIM    184429
 3D Structure    ModBase 3D Structure for P48431
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Chicken, Bovine, Canine
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 Specificity    This antibody recognizes ~35 kDa of human SOX-2 protein. It also reacts with mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide derived from N-terminus of Human SOX-2 protein. This sequence is identical among human, rat, mouse, bovine, chicken, and dog.
 Positive Control    Mouse embryonic brain
 Cellular Location    Nuclear
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-SOX-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOX-2 antibody

   The SOX2 is a transcription factor, a member of the SRY-related HMG-box (SOX) family involved in the regulation of embryonic development and in the determination of cell fate. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. When SOX-2 is expressed in self-renewing progenitor cells, it acts to inhibit neuronal differentiation. Sox-2 is considered as an appropriate cell-specific marker in vivo dynamics of the neural progenitor cell compartment as well as in the adult brain.
 Applications Tested/Suitable for anti-SOX-2 antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-SOX-2 antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 2-5 ug/ml
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 Immunohistochemistry of anti-SOX-2 antibody    mouse stem cells was stained by Rabbit anti-SOX-2 at 1:250, and visualized by FITClabled anti Rabbit IgG. The nuclear staining is observed.
anti-SOX-2 antibody Immunohistochemistry (IHC) image
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  Western Blot of anti-SOX-2 antibody    The whole cell lysate derived from embryonic mouse brain immunoblotted by Rabbit anti-SOX-2 at 1:500
anti-SOX-2 antibody  Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for SOX-2. It may not necessarily be applicable to this product.
 NCBI GI #    854182
 NCBI GeneID    6657
 NCBI Accession #    CAA83435.1 [Other Products]
 NCBI GenBank Nucleotide #    Z31560.1 [Other Products]
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 UniProt Primary Accession #    P48431 [Other Products]
 UniProt Secondary Accession #    Q14537 [Other Products]
 UniProt Related Accession #    P48431 [Other Products]
 Molecular Weight    35 kDa
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 NCBI Official Full Name    sox-2
 NCBI Official Synonym Full Names    SRY (sex determining region Y)-box 2
 NCBI Official Symbol    SOX2 [Similar Products]
 NCBI Official Synonym Symbols   
ANOP3; MCOPS3; MGC2413
[Similar Products]
 NCBI Protein Information    transcription factor SOX-2; OTTHUMP00000212684; transcription factor SOX2; SRY-related HMG-box gene 2
 UniProt Protein Name    Transcription factor SOX-2
 Protein Family    Transcription factor
 UniProt Gene Name    SOX2 [Similar Products]
 UniProt Entry Name    SOX2_HUMAN
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 NCBI Summary for SOX-2    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]
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 UniProt Comments for SOX-2    Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206

By similarity. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation

By similarity. Ref.5

Subunit structure: Interacts with ZSCAN10

By similarity. Interacts with SOX3 and FGFR1

Subcellular location: Nucleus.

Post-translational modification: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation

Involvement in disease: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [

MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Ref.4

Biotechnological use: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differenciated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.5

Sequence similarities: Contains 1 HMG box DNA-binding domain.

Sequence caution: The sequence AAA35997.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA83435.1 differs from that shown. Reason: Erroneous initiation.
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Product References and Citations for anti-SOX-2 antibody

   Mila Komitova and Peter S. Eriksson. Sox-2 is expressed by neural progenitors and astroglia in the adult rat brain Neuroscience Letters Volume 369, Issue 1, 7 October 2004, Pages 24-27
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 Research Articles on SOX-2    1. Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOX-2 antibodyPathways associated with anti-SOX-2 antibody
 Reference Product  PubMed Publications
 POU5F1 antibody  >318 publications with SOX-2 and POU5F1
 POU2F1 antibody  >5 publications with SOX-2 and POU2F1
 NR5A1 antibody  >1 publications with SOX-2 and NR5A1
 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram
Diseases associated with anti-SOX-2 antibodyOrgans/Tissues associated with anti-SOX-2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >242 publications with SOX-2 and Neoplasms
 Central Nervous System Diseases Antibodies  >69 publications with SOX-2 and Central Nervous System Diseases
 Eye Abnormalities Antibodies  >59 publications with SOX-2 and Eye Abnormalities
 Carcinoma, Embryonal Antibodies  >55 publications with SOX-2 and Carcinoma, Embryonal
 Leukemia Antibodies  >54 publications with SOX-2 and Leukemia
 Male Urogenital Diseases Antibodies  >35 publications with SOX-2 and Male Urogenital Diseases
 Genital Diseases, Male Antibodies  >33 publications with SOX-2 and Genital Diseases, Male
 Anophthalmos Antibodies  >31 publications with SOX-2 and Anophthalmos
 Cardiovascular Diseases Antibodies  >28 publications with SOX-2 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >23 publications with SOX-2 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >304 publications with SOX-2 and Embryonic Tissue
 Brain Antibodies  >256 publications with SOX-2 and Brain
 Eye Antibodies  >130 publications with SOX-2 and Eye
 Muscle Antibodies  >80 publications with SOX-2 and Muscle
 Lung Antibodies  >52 publications with SOX-2 and Lung
 Ear Antibodies  >44 publications with SOX-2 and Ear
 Testis Antibodies  >35 publications with SOX-2 and Testis
 Mouth Antibodies  >24 publications with SOX-2 and Mouth
 Pituitary Gland Antibodies  >22 publications with SOX-2 and Pituitary Gland
 Placenta Antibodies  >18 publications with SOX-2 and Placenta
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