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anti-SP1 antibody :: Rabbit SP1 Antibody

Scan QR to view Datasheet Catalog #    MBS8506900
Western Blot
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SP1, Antibody

★Popular Item★
 Also Known As   

Phospho-SP1 (Thr453) Antibody

 Product Synonym Names    TSFP1; Transcription factor SP1; transcription factor Sp1
 Product Gene Name   

anti-SP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    189906
 3D Structure    ModBase 3D Structure for P08047
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-SP1 (Thr453) Antibody detects endogenous levels of SP1 only when phosphorylated at Threonine 453
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
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 Immunogen    A synthesized peptide derived from human SP1 around the phosphorylation site of Threonine 453
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 Preparation and Storage    Store at -20C/ 1 year
 Other Notes    Small volumes of anti-SP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SP1 antibody

   SP1 is a transcription factor of the Sp1 C2H2-type zinc finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus.
 Applications Tested/Suitable for anti-SP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-SP1 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
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 Western Blot of anti-SP1 antibody    Western blot analysis of SP1 phosphorylation expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
anti-SP1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for SP1. It may not necessarily be applicable to this product.
 NCBI GI #    13638437
 NCBI GeneID    6667
 NCBI Accession #    P08047.3 [Other Products]
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 UniProt Primary Accession #    P08047 [Other Products]
 UniProt Secondary Accession #    Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7; E4Z9M7; G5E9M8 [Other Products]
 UniProt Related Accession #    P08047 [Other Products]
 Molecular Weight    90kDa
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 NCBI Official Full Name    Transcription factor Sp1
 NCBI Official Synonym Full Names    Sp1 transcription factor
 NCBI Official Symbol    SP1 [Similar Products]
 NCBI Protein Information    transcription factor Sp1; specificity protein 1
 UniProt Protein Name    Transcription factor Sp1
 Protein Family    Sp110 nuclear body protein
 UniProt Gene Name    SP1 [Similar Products]
 UniProt Synonym Gene Names    TSFP1 [Similar Products]
 UniProt Entry Name    SP1_HUMAN
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 NCBI Summary for SP1    The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
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 UniProt Comments for SP1    SP1: a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein C-terminus binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor activity; transcription factor binding

Biological Process: transcription initiation from RNA polymerase II promoter; ossification; embryonic placenta development; viral reproduction; transcription, DNA-dependent; megakaryocyte differentiation; embryonic skeletal development; positive regulation of transcription, DNA-dependent; embryonic process involved in female pregnancy; rhythmic process; cellular lipid metabolic process; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development
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 Research Articles on SP1    1. the mechanism of transcriptional activation of LTBP3 promoter depends on MALAT1 initiated from neighboring gene LTBP3 and involves both the direct interaction of the Sp1 and promoter-specific activation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SP1 antibodyPathways associated with anti-SP1 antibody
 Reference Product  PubMed Publications
 SP3 antibody  >1238 publications with SP1 and SP3
 MYC antibody  >293 publications with SP1 and MYC
 HDAC1 antibody  >103 publications with SP1 and HDAC1
 E2F1 antibody  >89 publications with SP1 and E2F1
 TP53 antibody  >51 publications with SP1 and TP53
 SMAD2 antibody  >41 publications with SP1 and SMAD2
 SMAD4 antibody  >41 publications with SP1 and SMAD4
 HDAC2 antibody  >39 publications with SP1 and HDAC2
 EP300 antibody  >21 publications with SP1 and EP300
 ESR1 antibody  >17 publications with SP1 and ESR1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
Diseases associated with anti-SP1 antibodyOrgans/Tissues associated with anti-SP1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >344 publications with SP1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >285 publications with SP1 and Nervous System Diseases
 Liver Diseases Antibodies  >271 publications with SP1 and Liver Diseases
 Necrosis Antibodies  >268 publications with SP1 and Necrosis
 Cardiovascular Diseases Antibodies  >230 publications with SP1 and Cardiovascular Diseases
 Inflammation Antibodies  >226 publications with SP1 and Inflammation
 Liver Neoplasms Antibodies  >206 publications with SP1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >203 publications with SP1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >186 publications with SP1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >183 publications with SP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >323 publications with SP1 and Bone
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