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anti-SREBP-1 antibody :: anti-Human, Rat SREBP-1 Antibody

Scan QR to view Datasheet Catalog #    MBS854001
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SREBP-1, Antibody

 Also Known As   

SREBP-1 (Ab-439) Antibody

 Product Synonym Names    SRBP1; SREBF1; SREBP1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
 Product Gene Name   

anti-SREBP-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    184756
 3D Structure    ModBase 3D Structure for P36956
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 Species Reactivity    Human, Rat
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 Specificity    SREBP-1 (Ab-439) antibody detects endogenous levels of total SREBP-1 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human SREBP-1 around the phosphorylation site of serine 439 (Q-S-SP-P-L).
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-SREBP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SREBP-1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-SREBP-1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SREBP-1 antibody    WB: 1:500~1:1000
ELISA: 1:20000
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 Western Blot (WB) of anti-SREBP-1 antibody    Western blot analysis of extracts from Jurkat cells, treated with TNF (200ng/ml, 30mins), using SREBP-1 (Ab-439) antibody.
anti-SREBP-1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SREBP-1. It may not necessarily be applicable to this product.
 NCBI GI #    52630419
 NCBI GeneID    6720
 NCBI Accession #    NP_001005291.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005291.2 [Other Products]
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 UniProt Primary Accession #    P36956 [Other Products]
 UniProt Secondary Accession #    Q16062; Q59F52; Q6P4R7; Q6PFW7; Q6PJ36; Q8TAK9; B0I4X3; B0I4X4; D3DXC4 [Other Products]
 UniProt Related Accession #    P36956 [Other Products]
 Molecular Weight    45,816 Da
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 NCBI Official Full Name    sterol regulatory element-binding protein 1 isoform a
 NCBI Official Synonym Full Names    sterol regulatory element binding transcription factor 1
 NCBI Official Symbol    SREBF1 [Similar Products]
 NCBI Official Synonym Symbols   
SREBP1; bHLHd1
[Similar Products]
 NCBI Protein Information    sterol regulatory element-binding protein 1
 UniProt Protein Name    Sterol regulatory element-binding protein 1
 UniProt Synonym Protein Names   
Class D basic helix-loop-helix protein 1; bHLHd1
 UniProt Gene Name    SREBF1 [Similar Products]
 UniProt Synonym Gene Names    BHLHD1; SREBP1; SREBP-1; bHLHd1 [Similar Products]
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 NCBI Summary for SREBP-1    This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
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 UniProt Comments for SREBP-1    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
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Product References and Citations for anti-SREBP-1 antibody

   Yokoyama C., Cell 75:187-197(1993). Hua X., Genomics 25:667-673(1995). Olsen J.V., Cell 127:635-648(2006).
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 Research Articles on SREBP-1    1. common SNPs (rs62064119, rs2297508, rs11868035 and rs13306741) in the SREBP-1c gene were selected and genotyped in 593 Han patients with NAFLD and 593 healthy controls. No significant differences in genotype and allele frequencies of these four SNPs were found between cases and controls, suggesting that the SNPs are not associated with risk of NAFLD in the Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SREBP-1 antibodyPathways associated with anti-SREBP-1 antibody
 Reference Product  PubMed Publications
 SP1 antibody  >42 publications with SREBP-1 and SP1
 YY1 antibody  >7 publications with SREBP-1 and YY1
 MAPK1 antibody  >5 publications with SREBP-1 and MAPK1
 LMNA antibody  >5 publications with SREBP-1 and LMNA
 MAPK3 antibody  >4 publications with SREBP-1 and MAPK3
 CREBBP antibody  >3 publications with SREBP-1 and CREBBP
 ID3 antibody  >2 publications with SREBP-1 and ID3
 TWIST2 antibody  >1 publications with SREBP-1 and TWIST2
 NR0B1 antibody  >1 publications with SREBP-1 and NR0B1
 ESR1 antibody  >1 publications with SREBP-1 and ESR1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
Diseases associated with anti-SREBP-1 antibodyOrgans/Tissues associated with anti-SREBP-1 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >369 publications with SREBP-1 and Fatty Liver
 Liver Diseases Antibodies  >182 publications with SREBP-1 and Liver Diseases
 Obesity Antibodies  >156 publications with SREBP-1 and Obesity
 Insulin Resistance Antibodies  >132 publications with SREBP-1 and Insulin Resistance
 Neoplasms Antibodies  >68 publications with SREBP-1 and Neoplasms
 Dyslipidemias Antibodies  >68 publications with SREBP-1 and Dyslipidemias
 Cardiovascular Diseases Antibodies  >63 publications with SREBP-1 and Cardiovascular Diseases
 Hyperlipidemias Antibodies  >62 publications with SREBP-1 and Hyperlipidemias
 Atherosclerosis Antibodies  >57 publications with SREBP-1 and Atherosclerosis
 Inflammation Antibodies  >38 publications with SREBP-1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >542 publications with SREBP-1 and Liver
 Blood Antibodies  >227 publications with SREBP-1 and Blood
 Connective Tissue Antibodies  >130 publications with SREBP-1 and Connective Tissue
 Muscle Antibodies  >100 publications with SREBP-1 and Muscle
 Kidney Antibodies  >49 publications with SREBP-1 and Kidney
 Brain Antibodies  >43 publications with SREBP-1 and Brain
 Pancreas Antibodies  >36 publications with SREBP-1 and Pancreas
 Vascular Antibodies  >36 publications with SREBP-1 and Vascular
 Heart Antibodies  >26 publications with SREBP-1 and Heart
 Thyroid Antibodies  >23 publications with SREBP-1 and Thyroid
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