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anti-SRY antibody :: Rabbit anti-Human SRY Antibody

Scan QR to view Datasheet Catalog #    MBS000466 anti-SRY antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SRY, Antibody

 Also Known As   

Rabbit SRY Antibody

 Product Gene Name   

anti-SRY antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: Y; NC_000024.9 (2654896..2655792, complement). Location: Yp11.3
 OMIM    400044
 3D Structure    ModBase 3D Structure for Q05066
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-SRY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SRY antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SRY. It may not necessarily be applicable to this product.
 NCBI GI #    4507225
 NCBI GeneID    6736
 NCBI Accession #    NP_003131.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003140.1 [Other Products]
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 UniProt Primary Accession #    Q05066 [Other Products]
 UniProt Related Accession #    Q05066 [Other Products]
 Molecular Weight    23,884 Da
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 NCBI Official Full Name    sex-determining region Y protein
 NCBI Official Synonym Full Names    sex determining region Y
 NCBI Official Symbol    SRY [Similar Products]
 NCBI Official Synonym Symbols   
TDF; TDY; SRXX1; SRXY1
[Similar Products]
 NCBI Protein Information    sex-determining region Y protein; testis-determining factor; sex-determining region on Y; sex determining region protein; essential protein for sex determination in human males
 UniProt Protein Name    Sex-determining region Y protein
 UniProt Synonym Protein Names   
Testis-determining factor
 Protein Family    SRY-related protein
 UniProt Gene Name    SRY [Similar Products]
 UniProt Synonym Gene Names    TDF [Similar Products]
 UniProt Entry Name    SRY_HUMAN
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 NCBI Summary for SRY    This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SRY    SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family.

Protein type: DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Yp11.3

Cellular Component: cytoplasm; nuclear speck; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; calmodulin binding; DNA binding; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; male sex determination; cell differentiation; sex differentiation

Disease: 46,xx Sex Reversal 1; 46,xy Sex Reversal 1
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 Research Articles on SRY    1. A novel SRY mutation leads to asymmetric SOX9 activation and is responsible for mixed 46,XY gonadal dysgenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SRY antibodyPathways associated with anti-SRY antibody
 Reference Product  PubMed Publications
 SMAD3 antibody  >9 publications with SRY and SMAD3
 Products by Pathway  Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
Diseases associated with anti-SRY antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >129 publications with SRY and Heart Diseases
 Nervous System Diseases Antibodies  >72 publications with SRY and Nervous System Diseases
 Kidney Diseases Antibodies  >35 publications with SRY and Kidney Diseases
 46,XY SEX REVERSAL 1 Antibodies  >34 publications with SRY and 46,XY SEX REVERSAL 1
 Hyperplasia Antibodies  >31 publications with SRY and Hyperplasia
 46,Xx Gonadal Dysgenesis, Complete, Sry-Positive Antibodies  >23 publications with SRY and 46,Xx Gonadal Dysgenesis, Complete, Sry-Positive
 Liver Diseases Antibodies  >22 publications with SRY and Liver Diseases
 Adenocarcinoma Antibodies  >21 publications with SRY and Adenocarcinoma
 Necrosis Antibodies  >17 publications with SRY and Necrosis
 Inflammation Antibodies  >14 publications with SRY and Inflammation
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