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anti-SIRPA antibody :: Rabbit Sirp alpha 1 Antibody

Scan QR to view Datasheet Catalog #    MBS853893
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sirp alpha 1 (SIRPA), Antibody

 Also Known As   

Sirp alpha 1 Antibody

 Product Synonym Names    Sirp a1 Antibody; Bit; MFR; MYD-1 antigen; MYD1; Macrophage fusion receptor; PTPNS1; SHP substrate-1; SHPS-1; SHS1; SIRP; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3; brain Ig-like molecule with tyrosine-based activation motifs; inhibitory receptor SHPS-1; p84; protein-tyrosi
 Product Gene Name   

anti-SIRPA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602461
 3D Structure    ModBase 3D Structure for P78324
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Sirp alpha1 antibody detects endogenous levels of total Sirp alpha1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized peptide derived from human SIRP-alpha1.
 Pathway    Intermediates
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-SIRPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SIRPA antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-SIRPA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-SIRPA antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000
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 Testing Data of anti-SIRPA antibody    Peptide - +
Immunohistochemical analysis of paraffin-embedded human brain tissue using Sirp alpha1 antibody (#C0322).
anti-SIRPA antibody Testing Data image
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 Testing Data #2 of anti-SIRPA antibody    Western blot analysis of extracts from HepG2 cells, using Sirp alpha1 antibody (#C0322).
anti-SIRPA antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for SIRPA. It may not necessarily be applicable to this product.
 NCBI GI #    91105764
 NCBI GeneID    140885
 NCBI Accession #    NP_001035111.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040022.1 [Other Products]
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 UniProt Primary Accession #    P78324 [Other Products]
 UniProt Secondary Accession #    O00683; O43799; Q8N517; Q8TAL8; Q9H0Z2; Q9UDX2; Q9UIJ6; Q9Y4U9; A2A2E1; A8K411; B2R6C3 [Other Products]
 UniProt Related Accession #    P78324 [Other Products]
 Molecular Weight    54,852 Da [Similar Products]
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type substrate 1
 NCBI Official Synonym Full Names    signal-regulatory protein alpha
 NCBI Official Symbol    SIRPA [Similar Products]
 NCBI Official Synonym Symbols   
BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type substrate 1
 UniProt Synonym Protein Names   
Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD_antigen: CD172a
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    SIRPA [Similar Products]
 UniProt Synonym Gene Names    BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3 [Similar Products]
 UniProt Entry Name    SHPS1_HUMAN
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 NCBI Summary for SIRPA    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIRPA    SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion; Cell surface

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: SH3 domain binding

Biological Process: cell adhesion; blood coagulation; leukocyte migration
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Product References and Citations for anti-SIRPA antibody

   Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066.
Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127.
Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301.
Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452.
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 Research Articles on SIRPA    1. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SIRPA antibodyDiseases associated with anti-SIRPA antibody
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies  Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >22 publications with SIRPA and Inflammation
 Cardiovascular Diseases Antibodies  >15 publications with SIRPA and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >9 publications with SIRPA and Breast Neoplasms
 Disease Models, Animal Antibodies  >8 publications with SIRPA and Disease Models, Animal
 Necrosis Antibodies  >8 publications with SIRPA and Necrosis
 Respiratory Tract Diseases Antibodies  >6 publications with SIRPA and Respiratory Tract Diseases
 Kidney Diseases Antibodies  >5 publications with SIRPA and Kidney Diseases
 Lung Diseases Antibodies  >5 publications with SIRPA and Lung Diseases
 Infertility, Male Antibodies  >4 publications with SIRPA and Infertility, Male
 Cell Transformation, Neoplastic Antibodies  >3 publications with SIRPA and Cell Transformation, Neoplastic
Organs/Tissues associated with anti-SIRPA antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with SIRPA and Blood
 Bone Antibodies  >19 publications with SIRPA and Bone
 Muscle Antibodies  >18 publications with SIRPA and Muscle
 Vascular Antibodies  >18 publications with SIRPA and Vascular
 Prostate Antibodies  >13 publications with SIRPA and Prostate
 Eye Antibodies  >10 publications with SIRPA and Eye
 Lung Antibodies  >9 publications with SIRPA and Lung
 Bone Marrow Antibodies  >9 publications with SIRPA and Bone Marrow
 Skin Antibodies  >8 publications with SIRPA and Skin
 Heart Antibodies  >7 publications with SIRPA and Heart
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