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anti-Smad3 antibody :: Rabbit Smad3 (Phospho-Ser208) Antibody

Scan QR to view Datasheet Catalog #    MBS001964 anti-Smad3 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Smad3 (Phospho-Ser208), Antibody

 Also Known As   

Rabbit Smad3 (Phospho-Ser208) Antibody

 Product Gene Name   

anti-Smad3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (67358195..67487533). Location: 15q22.33
 OMIM    114500
 3D Structure    ModBase 3D Structure for P84022
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-Smad3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Smad3 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for Smad3. It may not necessarily be applicable to this product.
 NCBI GI #    223029440
 NCBI GeneID    4088
 NCBI Accession #    NP_001138574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145102.1 [Other Products]
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 UniProt Primary Accession #    P84022 [Other Products]
 UniProt Secondary Accession #    O09064; O09144; O14510; O35273; Q92940; Q93002; A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383 [Other Products]
 UniProt Related Accession #    P84022 [Other Products]
 Molecular Weight    48,081 Da
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 NCBI Official Full Name    mothers against decapentaplegic homolog 3 isoform 2
 NCBI Official Synonym Full Names    SMAD family member 3
 NCBI Official Symbol    SMAD3 [Similar Products]
 NCBI Official Synonym Symbols   
LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3
 UniProt Protein Name    Mothers against decapentaplegic homolog 3
 UniProt Synonym Protein Names   
JV15-2; SMAD family member 3
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD3 [Similar Products]
 UniProt Synonym Gene Names    MADH3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; SMAD 3; Smad3; hSMAD3 [Similar Products]
 UniProt Entry Name    SMAD3_HUMAN
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 NCBI Summary for Smad3    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
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 UniProt Comments for Smad3    SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.

Protein type: DNA-binding; Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 15q22.33

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; cytoplasm; plasma membrane; nuclear inner membrane; cytosol; nucleus; receptor complex

Molecular Function: identical protein binding; ubiquitin binding; protein homodimerization activity; zinc ion binding; chromatin DNA binding; beta-catenin binding; protein kinase binding; transcription factor binding; phosphatase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; collagen binding; protein binding; sequence-specific DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; bHLH transcription factor binding; transforming growth factor beta receptor binding; transcription factor activity

Biological Process: developmental growth; positive regulation of positive chemotaxis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; embryonic pattern specification; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; embryonic foregut morphogenesis; negative regulation of mitotic cell cycle; negative regulation of osteoblast differentiation; cell cycle arrest; regulation of striated muscle development; pericardium development; somitogenesis; transcription, DNA-dependent; embryonic cranial skeleton morphogenesis; osteoblast development; regulation of transcription from RNA polymerase II promoter; positive regulation of chondrocyte differentiation; mesoderm formation; negative regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein catabolic process; endoderm development; negative regulation of apoptosis; evasion of host defenses by virus; wound healing; T cell activation; negative regulation of transcription from RNA polymerase II promoter; primary microRNA processing; regulation of epithelial cell proliferation; positive regulation of focal adhesion formation; negative regulation of protein amino acid phosphorylation; ureteric bud development; transport; positive regulation of transforming growth factor-beta3 production; thyroid gland development; positive regulation of transcription factor import into nucleus; heart looping; caspase activation; transcription initiation from RNA polymerase II promoter; intercellular junction assembly and maintenance; regulation of transforming growth factor-beta2 production; regulation of immune response; regulation of binding; protein stabilization; in utero embryonic development; positive regulation of bone mineralization; liver development; SMAD protein complex assembly; immune system development; positive regulation of interleukin-1 beta production; negative regulation of inflammatory response; response to hypoxia; gene expression; immune response; negative regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration

Disease: Loeys-dietz Syndrome 3
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 Research Articles on Smad3    1. Smad3, pSmad3L(T179), and pSmad3L(S213) expression might be independent predictors of both shorter disease-free survival and shorter overall survival in gastric carcinoma patients after curative surgery.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Smad3 antibodyPathways associated with anti-Smad3 antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >1384 publications with Smad3 and SMAD2
 SMAD4 antibody  >729 publications with Smad3 and SMAD4
 JUN antibody  >407 publications with Smad3 and JUN
 SMAD1 antibody  >169 publications with Smad3 and SMAD1
 MYC antibody  >88 publications with Smad3 and MYC
 CTNNB1 antibody  >85 publications with Smad3 and CTNNB1
 SP1 antibody  >72 publications with Smad3 and SP1
 SKI antibody  >63 publications with Smad3 and SKI
 MAPK1 antibody  >44 publications with Smad3 and MAPK1
 RUNX2 antibody  >37 publications with Smad3 and RUNX2
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-Smad3 antibodyOrgans/Tissues associated with anti-Smad3 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >674 publications with Smad3 and Fibrosis
 Neoplasms Antibodies  >581 publications with Smad3 and Neoplasms
 Disease Models, Animal Antibodies  >245 publications with Smad3 and Disease Models, Animal
 Inflammation Antibodies  >244 publications with Smad3 and Inflammation
 Liver Diseases Antibodies  >175 publications with Smad3 and Liver Diseases
 Kidney Diseases Antibodies  >152 publications with Smad3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >145 publications with Smad3 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >100 publications with Smad3 and Breast Neoplasms
 Necrosis Antibodies  >92 publications with Smad3 and Necrosis
 Liver Cirrhosis Antibodies  >91 publications with Smad3 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >452 publications with Smad3 and Muscle
 Lung Antibodies  >276 publications with Smad3 and Lung
 Skin Antibodies  >195 publications with Smad3 and Skin
 Heart Antibodies  >143 publications with Smad3 and Heart
 Embryonic Tissue Antibodies  >137 publications with Smad3 and Embryonic Tissue
 Intestine Antibodies  >56 publications with Smad3 and Intestine
 Thyroid Antibodies  >28 publications with Smad3 and Thyroid
 Ascites Antibodies  >1 publications with Smad3 and Ascites
 Uncharacterized Tissue Antibodies  >1 publications with Smad3 and Uncharacterized Tissue
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