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anti-BIRC5 antibody :: Rabbit Survivin (CT) Antibody

Scan QR to view Datasheet Catalog #    MBS194143 anti-BIRC5 antibody
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Survivin (CT) (BIRC5), Antibody

 Also Known As   

Anti-Survivin (CT) Antibody

 Product Synonym Names    Anti-Survivin (CT); Survivin (CT)
 Product Gene Name   

anti-BIRC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8I009
 Host    Rabbit
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 Specificity    Anti-Survivin (CT) [Rabbit antibody to peptide corresponding to aa 129 to aa 129-142 of human survivin.]
This antibody recognizes human survivin (17 kD).
 Form/Format    100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to aa 129-142 of human survivin.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-BIRC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BIRC5 antibody

   Apoptosis is related to many diseases and is triggered by a variety of stimuli including members of the TNF family. Apoptosis can be prevented by the inhibitor of apoptosis proteins (IAPs). IAPs constitute a conserved gene family that binds to and inhibits cell death proteases. A novel IAP has been identified and designated survivin. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is expressed predominantly in tissues of embryos, transformed cell lines, and many human cancers.
 Product Categories/Family for anti-BIRC5 antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-BIRC5 antibody   

Immunoblot

 Application Notes for anti-BIRC5 antibody    Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: MOLT4 cell lysate.
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NCBI/Uniprot data below describe general gene information for BIRC5. It may not necessarily be applicable to this product.
 NCBI GI #    50978646
 NCBI GeneID    403540
 NCBI Accession #    NP_001003019.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003019.1 [Other Products]
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 UniProt Primary Accession #    Q8I009 [Other Products]
 UniProt Secondary Accession #    Q5XPZ7; Q6L673 [Other Products]
 UniProt Related Accession #    Q8I009 [Other Products]
 Molecular Weight    16,271 Da [Similar Products]
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 NCBI Official Full Name    baculoviral IAP repeat-containing protein 5
 NCBI Official Symbol    BIRC5 [Similar Products]
 NCBI Official Synonym Symbols   
BIRC5
[Similar Products]
 NCBI Protein Information    baculoviral IAP repeat-containing protein 5; survivin; apoptosis inhibitor survivin
 UniProt Protein Name    Baculoviral IAP repeat-containing protein 5
 UniProt Synonym Protein Names   
Apoptosis inhibitor survivin
 Protein Family    Baculoviral IAP repeat-containing protein
 UniProt Gene Name    BIRC5 [Similar Products]
 UniProt Entry Name    BIRC5_CANFA
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 UniProt Comments for BIRC5    Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7

Subunit structure: Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state

By similarity. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Chromosome › centromere

By similarity. Cytoplasm › cytoskeleton › spindle

By similarity. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes

By similarity. UniProtKB O15392

Domain: The BIR repeat is necessary and sufficient for HBXIP binding

Post-translational modification: Ubiquitination is required for centrosomal targeting

By similarity.In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes

Sequence similarities: Belongs to the IAP family.Contains 1 BIR repeat.
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 Research Articles on BIRC5    1. This study demonstrated survivin expression in normal canine epidermis; nuclear survivin expression in pre-neoplastic and neoplastic lesions demonstrated a possible association of survivin with development of squamous cell carcinomas in humans and dogs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BIRC5 antibodyDiseases associated with anti-BIRC5 antibody
 Products by Pathway  Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1899 publications with BIRC5 and Neoplasms
 Carcinoma Antibodies  >798 publications with BIRC5 and Carcinoma
 Adenocarcinoma Antibodies  >318 publications with BIRC5 and Adenocarcinoma
 Breast Neoplasms Antibodies  >201 publications with BIRC5 and Breast Neoplasms
 Lung Neoplasms Antibodies  >188 publications with BIRC5 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >184 publications with BIRC5 and Neoplasm Metastasis
 Head and Neck Neoplasms Antibodies  >182 publications with BIRC5 and Head and Neck Neoplasms
 Leukemia Antibodies  >177 publications with BIRC5 and Leukemia
 Colorectal Neoplasms Antibodies  >172 publications with BIRC5 and Colorectal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >170 publications with BIRC5 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-BIRC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Female Genital Antibodies  >30 publications with BIRC5 and Female Genital
 Lymphoreticular Antibodies  >1 publications with BIRC5 and Lymphoreticular
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