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anti-BIRC5 antibody :: Survivin Antibody

Scan QR to view Datasheet Catalog #    MBS8511201
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Survivin (BIRC5), Antibody

★Popular Item★
 Also Known As   

Phospho-Survivin (Thr117) Antibody

 Product Synonym Names    API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; Baculoviral IAP repeat-containing protein 5; IAP4; TIAP
 Product Gene Name   

anti-BIRC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603352
 3D Structure    ModBase 3D Structure for O15392
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-Survivin (Thr117) Antibody detects endogenous levels of Survivin only when phosphorylated at Threonine 117
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline, pH 7.4 150mM NaCI, 0.02% sodium azide and 50% glycerol.
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 Immunogen    A synthesized peptide derived from human Survivin around the phosphorylation site of Threonine 117
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 Preparation and Storage    Store at -20C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-BIRC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BIRC5 antibody

   Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia.
 Applications Tested/Suitable for anti-BIRC5 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-BIRC5 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
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 Western Blot (WB) of anti-BIRC5 antibody    Western blot analysis of Survivin phosphorylation expression in A549 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
anti-BIRC5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BIRC5. It may not necessarily be applicable to this product.
 NCBI GI #    59859880
 NCBI GeneID    332
 NCBI Accession #    NP_001012270.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012270.1 [Other Products]
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 UniProt Primary Accession #    O15392 [Other Products]
 UniProt Secondary Accession #    Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8; A2SUH6; B2R4R1 [Other Products]
 UniProt Related Accession #    O15392 [Other Products]
 Molecular Weight    16kDa [Similar Products]
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 NCBI Official Full Name    baculoviral IAP repeat-containing protein 5 isoform 2
 NCBI Official Synonym Full Names    baculoviral IAP repeat containing 5
 NCBI Official Symbol    BIRC5 [Similar Products]
 NCBI Official Synonym Symbols   
API4; EPR-1
[Similar Products]
 NCBI Protein Information    baculoviral IAP repeat-containing protein 5
 UniProt Protein Name    Baculoviral IAP repeat-containing protein 5
 UniProt Synonym Protein Names   
Apoptosis inhibitor 4; Apoptosis inhibitor survivin
 Protein Family    Baculoviral IAP repeat-containing protein
 UniProt Gene Name    BIRC5 [Similar Products]
 UniProt Synonym Gene Names    API4; IAP4 [Similar Products]
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 NCBI Summary for BIRC5    This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
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 UniProt Comments for BIRC5    Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
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 Research Articles on BIRC5    1. Knockdown of BIRC5, a member of the inhibitor of apoptosis protein family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of epithelial to mesenchymal transition in retinal pigment epithelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BIRC5 antibodyPathways associated with anti-BIRC5 antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >419 publications with BIRC5 and CASP3
 XIAP antibody  >167 publications with BIRC5 and XIAP
 CASP9 antibody  >94 publications with BIRC5 and CASP9
 DIABLO antibody  >52 publications with BIRC5 and DIABLO
 INCENP antibody  >45 publications with BIRC5 and INCENP
 CASP7 antibody  >41 publications with BIRC5 and CASP7
 CDK4 antibody  >23 publications with BIRC5 and CDK4
 CDK1 antibody  >23 publications with BIRC5 and CDK1
 CDCA8 antibody  >22 publications with BIRC5 and CDCA8
 E2F1 antibody  >20 publications with BIRC5 and E2F1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
Diseases associated with anti-BIRC5 antibodyOrgans/Tissues associated with anti-BIRC5 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2403 publications with BIRC5 and Neoplasms
 Adenocarcinoma Antibodies  >390 publications with BIRC5 and Adenocarcinoma
 Gastrointestinal Diseases Antibodies  >363 publications with BIRC5 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >264 publications with BIRC5 and Breast Neoplasms
 Lung Neoplasms Antibodies  >245 publications with BIRC5 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >230 publications with BIRC5 and Neoplasm Metastasis
 Colorectal Neoplasms Antibodies  >211 publications with BIRC5 and Colorectal Neoplasms
 Carcinoma, Small Cell Antibodies  >207 publications with BIRC5 and Carcinoma, Small Cell
 Carcinoma, Squamous Cell Antibodies  >202 publications with BIRC5 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >173 publications with BIRC5 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >288 publications with BIRC5 and Lung
 Liver Antibodies  >198 publications with BIRC5 and Liver
 Lymph Node Antibodies  >158 publications with BIRC5 and Lymph Node
 Prostate Antibodies  >137 publications with BIRC5 and Prostate
 Brain Antibodies  >125 publications with BIRC5 and Brain
 Stomach Antibodies  >119 publications with BIRC5 and Stomach
 Bone Antibodies  >116 publications with BIRC5 and Bone
 Skin Antibodies  >101 publications with BIRC5 and Skin
 Embryonic Tissue Antibodies  >60 publications with BIRC5 and Embryonic Tissue
 Heart Antibodies  >41 publications with BIRC5 and Heart
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