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| Product Name
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Synuclein-alpha (SNCA), Antibody
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| Also Known As
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Synuclein-alpha (Ab-125) Antibody
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| Product Synonym Names
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Synuclein-a (Ab-125) Antibody; alpha-synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SYN; synuclein; alpha; SYUA
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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605543
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| 3D Structure
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ModBase 3D Structure for P37840
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| Host
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Rabbit
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| Species Reactivity
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Human, Mouse, Rat
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| Specificity
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Synuclein-alpha (Ab-125) antibody detects endogenous levels of total Synuclein-alpha protein.
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| Purity/Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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| Form/Format
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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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| Immunogen
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The antiserum was produced against synthesized non-phosphopeptide derived from human Synuclein-alpha around the phosphorylation site of tyrosine 125 (E-A-YP-E-M).
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| Pathway
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Neuroscience
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| Preparation and Storage
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Store at -20 degree C for 1 year
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| Other Notes
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Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for anti-SNCA antibody
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Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
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| Applications Tested/Suitable for anti-SNCA antibody
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Western Blot (WB), ELISA (EIA)
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| Application Notes for anti-SNCA antibody
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WB: 1:500~1:1000, ELISA: 1:40000
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| Testing Data of anti-SNCA antibody
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Western blot analysis of extracts from rat brain and mouse brain, using Synuclein-alpha (Ab-125) antibody.
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TOP
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| NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product. |
| NCBI GI #
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4507109
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| NCBI GeneID
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6622
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| NCBI Accession #
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NP_000336.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_000345.3
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[Other Products]
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| UniProt Primary Accession #
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P37840
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[Other Products]
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| UniProt Secondary Accession #
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Q13701; Q4JHI3; Q6IAU6; A8K2A4
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[Other Products]
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| UniProt Related Accession #
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P37840
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[Other Products]
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| Molecular Weight
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13,109 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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alpha-synuclein isoform NACP140
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| NCBI Official Synonym Full Names
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synuclein, alpha (non A4 component of amyloid precursor)
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| NCBI Official Symbol
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SNCA
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[Similar Products]
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| NCBI Official Synonym Symbols
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PD1; NACP; PARK1; PARK4
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[Similar Products]
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| NCBI Protein Information
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alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
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| UniProt Protein Name
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Alpha-synuclein
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| UniProt Synonym Protein Names
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Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
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| Protein Family
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Alpha-synuclein
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| UniProt Gene Name
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SNCA
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[Similar Products]
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| UniProt Synonym Gene Names
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NACP; PARK1; NACP
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[Similar Products]
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| UniProt Entry Name
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SYUA_HUMAN
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| NCBI Summary for SNCA
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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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| UniProt Comments for SNCA
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SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: Golgi apparatus; nuclear outer membrane; rough endoplasmic reticulum; mitochondrion; lysosome; extracellular region; fibril; terminal button; cell cortex; inclusion body; mitochondrial respiratory chain complex I; cytosol; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; nucleus; cell junction
Molecular Function: protein domain specific binding; identical protein binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; calcium ion binding; oxidoreductase activity; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; fatty acid binding; tau protein binding; alpha-tubulin binding
Biological Process: regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of caspase activity; negative regulation of monooxygenase activity; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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TOP
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Product References and Citations for anti-SNCA antibody
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Ueda K., Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993).
Campion D., Genomics 26:254-257(1995).
Ueda K., Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
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| Research Articles on SNCA
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1. results point to FOXO3 as an important determinant of neuronal survival in the substantia nigra, which may oppose alpha-synuclein accumulation and proteotoxicity.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-SNCA antibody | Pathways associated with anti-SNCA antibody |
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| Diseases associated with anti-SNCA antibody | Organs/Tissues associated with anti-SNCA antibody |
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Antibody 
