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anti-SNCA antibody :: Rabbit Synuclein-alpha Antibody

Scan QR to view Datasheet Catalog #    MBS853911
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synuclein-alpha (SNCA), Antibody

 Also Known As   

Synuclein-alpha (Ab-125) Antibody

 Product Synonym Names    Synuclein-a (Ab-125) Antibody; alpha-synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SYN; synuclein; alpha; SYUA
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605543
 3D Structure    ModBase 3D Structure for P37840
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Synuclein-alpha (Ab-125) antibody detects endogenous levels of total Synuclein-alpha protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human Synuclein-alpha around the phosphorylation site of tyrosine 125 (E-A-YP-E-M).
 Pathway    Neuroscience
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SNCA antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-SNCA antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SNCA antibody    WB: 1:500~1:1000, ELISA: 1:40000
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 Testing Data of anti-SNCA antibody    Western blot analysis of extracts from rat brain and mouse brain, using Synuclein-alpha (Ab-125) antibody.
anti-SNCA antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    4507109
 NCBI GeneID    6622
 NCBI Accession #    NP_000336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000345.3 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da [Similar Products]
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 NCBI Official Full Name    alpha-synuclein isoform NACP140
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; rough endoplasmic reticulum; mitochondrion; lysosome; extracellular region; fibril; terminal button; cell cortex; inclusion body; mitochondrial respiratory chain complex I; cytosol; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; nucleus; cell junction

Molecular Function: protein domain specific binding; identical protein binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; calcium ion binding; oxidoreductase activity; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; fatty acid binding; tau protein binding; alpha-tubulin binding

Biological Process: regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of caspase activity; negative regulation of monooxygenase activity; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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Product References and Citations for anti-SNCA antibody

   Ueda K., Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993).
Campion D., Genomics 26:254-257(1995).
Ueda K., Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
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 Research Articles on SNCA    1. results point to FOXO3 as an important determinant of neuronal survival in the substantia nigra, which may oppose alpha-synuclein accumulation and proteotoxicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >913 publications with SNCA and PARK2
 LRRK2 antibody  >133 publications with SNCA and LRRK2
 PARK7 antibody  >53 publications with SNCA and PARK7
 SNCAIP antibody  >32 publications with SNCA and SNCAIP
 SLC6A3 antibody  >12 publications with SNCA and SLC6A3
 BAD antibody  >3 publications with SNCA and BAD
 FYN antibody  >2 publications with SNCA and FYN
 GRK5 antibody  >1 publications with SNCA and GRK5
 STUB1 antibody  >1 publications with SNCA and STUB1
 UBC antibody  >1 publications with SNCA and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1140 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1119 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1107 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >980 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >908 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >862 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >280 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >166 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >141 publications with SNCA and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >56 publications with SNCA and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1003 publications with SNCA and Nerve
 Brain Antibodies  >785 publications with SNCA and Brain
 Blood Antibodies  >67 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >19 publications with SNCA and Kidney
 Heart Antibodies  >10 publications with SNCA and Heart
 Eye Antibodies  >10 publications with SNCA and Eye
 Bone Antibodies  >8 publications with SNCA and Bone
 Vascular Antibodies  >7 publications with SNCA and Vascular
 Liver Antibodies  >7 publications with SNCA and Liver
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