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anti-TERT antibody :: Rabbit TERT Antibody

Scan QR to view Datasheet Catalog #    MBS8500687
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TERT, Antibody

★Popular Item★
 Also Known As   

TERT Antibody

 Product Synonym Names    TP2; TRT; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
 Product Gene Name   

anti-TERT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    178500
 3D Structure    ModBase 3D Structure for O14746
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    A synthetic peptide of human TERT
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TERT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TERT antibody

   Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
 Product Categories/Family for anti-TERT antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-TERT antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TERT antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-TERT antibody    Western blot analysis of extracts of various celllines, using TERT antibody.
anti-TERT antibody Western Blot (WB) (WB) image
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 Testing Data of anti-TERT antibody    anti-TERT antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-TERT antibody    The image on the left is immunohistochemistryof paraffin-embedded Human tonsil tissue usingTERT Antibody.
anti-TERT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TERT. It may not necessarily be applicable to this product.
 NCBI GI #    301129200
 NCBI GeneID    7015
 NCBI Accession #    NP_001180305.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193376.1 [Other Products]
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 UniProt Primary Accession #    O14746 [Other Products]
 UniProt Secondary Accession #    O14783; Q2XS35; Q8N6C3; Q8NG38; Q8NG46 [Other Products]
 UniProt Related Accession #    O14746 [Other Products]
 Molecular Weight    120kDa
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 NCBI Official Full Name    telomerase reverse transcriptase isoform 2
 NCBI Official Synonym Full Names    telomerase reverse transcriptase
 NCBI Official Symbol    TERT [Similar Products]
 NCBI Official Synonym Symbols   
TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
[Similar Products]
 NCBI Protein Information    telomerase reverse transcriptase
 UniProt Protein Name    Telomerase reverse transcriptase
 UniProt Synonym Protein Names   
HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
 Protein Family    Tertiapin
 UniProt Gene Name    TERT [Similar Products]
 UniProt Synonym Gene Names    EST2; TCS1; TRT; TP2 [Similar Products]
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 NCBI Summary for TERT    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERT    Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
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 Research Articles on TERT    1. Mutations in the promoter of TERTp are common in patients with glioblastomas (GBMs) and oligodendrogliomas (ODGs). Mutations in IDH1 and MGMTp methylation and age under 55 were associated with favorable prognosis in diffuse gliomas and in cases with grade III AA (combined IDH-mutant and IDH-WT AA), TERTp mutant carriers had worse overall survival than TERTp WT carriers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TERT antibodyPathways associated with anti-TERT antibody
 Reference Product  PubMed Publications
 SRC antibody  >216 publications with TERT and SRC
 TEP1 antibody  >26 publications with TERT and TEP1
 MTOR antibody  >19 publications with TERT and MTOR
 TPP1 antibody  >13 publications with TERT and TPP1
 NCL antibody  >13 publications with TERT and NCL
 RELA antibody  >12 publications with TERT and RELA
 AKT1 antibody  >12 publications with TERT and AKT1
 PRKCA antibody  >10 publications with TERT and PRKCA
 PINX1 antibody  >8 publications with TERT and PINX1
 SMG6 antibody  >2 publications with TERT and SMG6
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL2 Signaling Events Mediated By PI3K Pathway antibodies  IL2 Signaling Events Mediated By PI3K Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Diseases associated with anti-TERT antibodyOrgans/Tissues associated with anti-TERT antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1842 publications with TERT and Neoplasms
 Drug Toxicity Antibodies  >1628 publications with TERT and Drug Toxicity
 Neoplasms, Experimental Antibodies  >311 publications with TERT and Neoplasms, Experimental
 Lung Diseases Antibodies  >298 publications with TERT and Lung Diseases
 Necrosis Antibodies  >294 publications with TERT and Necrosis
 Inflammation Antibodies  >273 publications with TERT and Inflammation
 Liver Neoplasms Antibodies  >242 publications with TERT and Liver Neoplasms
 Heart Diseases Antibodies  >215 publications with TERT and Heart Diseases
 Reperfusion Injury Antibodies  >200 publications with TERT and Reperfusion Injury
 Lung Neoplasms Antibodies  >174 publications with TERT and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2437 publications with TERT and Blood
 Lung Antibodies  >621 publications with TERT and Lung
 Embryonic Tissue Antibodies  >162 publications with TERT and Embryonic Tissue
 Uterus Antibodies  >98 publications with TERT and Uterus
 Thymus Antibodies  >85 publications with TERT and Thymus
 Connective Tissue Antibodies  >76 publications with TERT and Connective Tissue
 Lymph Antibodies  >51 publications with TERT and Lymph
 Lymph Node Antibodies  >50 publications with TERT and Lymph Node
 Ascites Antibodies  >13 publications with TERT and Ascites
 Uncharacterized Tissue Antibodies  >2 publications with TERT and Uncharacterized Tissue
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